Ethanol and povidone‐iodine (PVP‐I) are important microbicides that inactivate bacteria and viruses. The present study provides a review of literature data on the concentration‐dependent bactericidal and virucidal activity of ethanol and PVP‐I in vitro. A systematic search was performed using the meta‐database for biomedicine PubMed. Eventually, 74 studies with original data on the reduction of bacterial and viral infectivity using in vitro tests were analyzed. A safe bactericidal effect of ethanol can be expected at concentrations between 60% and 85%, and the exposure times vary between ≤0.5 and ≥5 min. Within an exposure of up to 5 min, 80%–90% ethanol also exerts virucidal/low‐level activity, which includes its action against enveloped viruses plus adeno‐, noro‐, and rotaviruses. For PVP‐I, the best bactericidal and virucidal/high‐level effect is present at a concentration range of approx. 0.08%–0.9% depending on the free iodine concentration. The maximum exposure times are 5 min for bacteria and 60 min for viruses. The available data may help optimize the significant inactivation of bacteria and viruses in various areas. However, as the conditions in application practice can vary, concrete recommendations for the application can only be derived to a limited extent.

中文翻译：

---

乙醇和聚维酮碘的杀菌和杀病毒活性。

乙醇和聚维酮碘（PVP-1）是使细菌和病毒失活的重要杀菌剂。本研究综述了乙醇和PVP-1在体外的浓度依赖性杀菌和杀病毒活性的文献资料。使用元数据库对生物医学PubMed进行了系统的搜索。最终，使用体外试验对74项利用细菌和病毒感染性降低的原始数据进行的研究进行了分析。在浓度为60％至85％之间时，可以预期乙醇的安全杀菌作用，暴露时间在≤0.5至≥5分钟之间变化。在长达5分钟的暴露时间内，80％–90％的乙醇还会发挥杀灭性/低水平活性，其中包括对包膜病毒以及腺病毒，诺如病毒和轮状病毒的作用。对于PVP-I，最佳的杀菌和杀病毒/高水平作用的浓度范围大约为。0.08％–0.9％，取决于游离碘的浓度。细菌的最大暴露时间为5分钟，病毒为60分钟。现有数据可能有助于优化各个领域中细菌和病毒的显着灭活。但是，由于申请实践中的条件可能会有所不同，因此只能在有限的程度上得出有关申请的具体建议。