Bacterial cellulose (BC) is a natural material produced by Acetobacter xylinum, widely used in wound dressings due to the high water‐holding capacity and great mechanical strength. In this paper, a novel antimicrobial dressing made from BC/methylglyoxal (MGO) composite with a dip‐coating method inspired by naturally antimicrobial Manuka honey is proposed, which to our best knowledge, has not yet to be reported. Characterizations by scanning electron microscope and atomic force microscopy show the interconnected nanostructure of BC and MGO and increase surface roughness of the BC/MGO composite. Thermal analysis indicates high temperature stability of both BC and BC/MGO, while compared with BC, BC/MGO exhibits slightly weaker thermal stability possibly due to reduction of hydrogen bonding and increase of crystallinity. Mechanical test confirms the strong mechanical property of BC and BC/MGO nanocomposite. From the disk diffusion antimicrobial test, the BC/MGO nanocomposite with highest MGO concentration (4%) shows great zone inhibition diameter (around 14.3, 12.3, 17.1, and 15.5 mm against Micrococcus luteus, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli). Compared with other antimicrobial wound dressing composite materials, the proposed BC/MGO nanocomposite has among the greatest antimicrobial property against broad‐spectrum bacteria, making it a promising antimicrobial dressing in chronic wounds care.

中文翻译：

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受自然启发的细菌纤维素/甲基乙二醛（BC / MGO）纳米复合材料，用于广谱抗菌伤口敷料。

细菌纤维素（BC）是木醋杆菌生产的天然材料由于具有高保水能力和极高的机械强度，被广泛用于伤口敷料中。本文提出了一种由BC /甲基乙二醛（MGO）复合材料制成的新型抗菌敷料，该浸出法的灵感来自于天然抗菌麦卢卡蜂蜜，据我们所知，目前尚无报道。通过扫描电子显微镜和原子力显微镜的表征显示了BC和MGO的相互连接的纳米结构，并增加了BC / MGO复合材料的表面粗糙度。热分析表明，BC和BC / MGO均具有高温稳定性，而与BC相比，BC / MGO的热稳定性稍弱，这可能是由于氢键的减少和结晶度的提高。力学测试证实了BC和BC / MGO纳米复合材料的强机械性能。黄褐球菌，铜绿假单胞菌，金黄色葡萄球菌和大肠杆菌）。与其他抗菌伤口敷料复合材料相比，建议的BC / MGO纳米复合材料对广谱细菌具有最大的抗菌性能，使其成为慢性伤口护理中有希望的抗菌敷料。