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Black tea benefits short‐chain fatty acid producers but inhibits genus Lactobacillus in the gut of healthy Sprague–Dawley rats
Journal of the Science of Food and Agriculture ( IF 4.1 ) Pub Date : 2020-08-18 , DOI: 10.1002/jsfa.10598
Ying Gao 1 , Yongquan Xu 1 , Junfeng Yin 1
Affiliation  

BACKGROUND The gut microbiota plays important roles in physiological and pathological processes of the host. The effect of black tea on the gut microbiota of healthy individuals remains unclear. RESULTS Healthy Sprague-Dawley (SD) rats were given black tea for 4 weeks, and cecum content, serum, intestinal, and hepatic samples were collected. The results showed that black tea increased α-diversity and modulated β-diversity of the gut microbiota. Additionally, black tea enriched several short-chain fatty acid (SCFA) producers but suppressed genus Lactobacillus. Further tests revealed that the enrichment of SCFA producers was associated with a decrease in the oxidative stress of cecum content caused by black tea, and related to increased luminal butyric acid levels and enhanced intestinal barrier function. The suppression of genus Lactobacillus was related to the increase in luminal total bile acids caused by black tea. In vitro tests showed that bile acids rather than black tea directly inhibited Lactobacillus strains. The reduction in genus Lactobacillus did not affect the effects of black tea on intestinal barrier function and lipid levels. CONCLUSION Our results implied that the effects of black tea on gut microbiota in healthy individuals are complex and provide a new perspective on the association among black tea, gut microbiota, and health. This article is protected by copyright. All rights reserved.

中文翻译:

红茶有益于短链脂肪酸生产者,但会抑制健康 Sprague-Dawley 大鼠肠道中的乳酸杆菌属

背景肠道微生物群在宿主的生理和病理过程中起着重要作用。红茶对健康个体肠道微生物群的影响尚不清楚。结果 健康的 Sprague-Dawley (SD) 大鼠被给予红茶 4 周,并收集盲肠含量、血清、肠道和肝脏样本。结果表明,红茶增加了肠道微生物群的α-多样性并调节了β-多样性。此外,红茶丰富了几种短链脂肪酸 (SCFA) 生产者,但抑制了乳酸杆菌属。进一步的测试表明,SCFA 生产者的富集与红茶引起的盲肠内容物氧化应激的减少有关,并与增加管腔丁酸水平和增强肠道屏障功能有关。乳杆菌属的抑制与红茶引起的管腔总胆汁酸增加有关。体外试验表明胆汁酸而不是红茶直接抑制乳杆菌菌株。乳酸杆菌属的减少不影响红茶对肠道屏障功能和脂质水平的影响。结论 我们的研究结果表明,红茶对健康个体肠道微生物群的影响是复杂的,并为红茶、肠道微生物群和健康之间的关联提供了新的视角。本文受版权保护。版权所有。乳酸杆菌属的减少不影响红茶对肠道屏障功能和脂质水平的影响。结论 我们的研究结果表明,红茶对健康个体肠道微生物群的影响是复杂的,并为红茶、肠道微生物群和健康之间的关联提供了新的视角。本文受版权保护。版权所有。乳酸杆菌属的减少不影响红茶对肠道屏障功能和脂质水平的影响。结论 我们的研究结果表明,红茶对健康个体肠道微生物群的影响是复杂的,并为红茶、肠道微生物群和健康之间的关联提供了新的视角。本文受版权保护。版权所有。
更新日期:2020-08-18
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