Alkaloids from marine secondary metabolites have received extensive attention from pharmacists in recent years. Miscellaneous alkaloids derived from marine sponges possessed various pharmacological activities including cytotoxicity, antimicrobial, antioxidant, and so on. Herein, we summarized 149 marine alkaloids from sponges based on their structures and bioactivities reported from 2015 to 2020 and analyzed the production environment of marine sponges with rich alkaloids. Moreover, we discussed biosynthesis routes of pyrrole and guanidine alkaloids from marine sponges Agelas and Monanchora. This article will be beneficial for future research on drugs from marine natural products.

中文翻译：

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海绵中海洋生物碱的研究进展

海洋次生代谢产物中的生物碱近年来受到药剂师的广泛关注。来源于海绵的各种生物碱具有多种药理活性，包括细胞毒性、抗菌、抗氧化等。在此，我们根据 2015 年至 2020 年报告的 149 种海绵海洋生物碱的结构和生物活性进行了总结，并分析了富含生物碱的海洋海绵的生产环境。此外，我们讨论了来自海洋海绵 Agelas 和 Monanchora 的吡咯和胍生物碱的生物合成路线。这篇文章将有利于未来海洋天然产物药物的研究。