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Natural killer cells and reproductive success.
American Journal of Reproductive Immunology ( IF 3.6 ) Pub Date : 2020-06-20 , DOI: 10.1111/aji.13291
Gavin Sacks 1, 2, 3 , Emma Finkelstein 2
Affiliation  

Natural killer (NK) cell assessment has been attempted since the 1990s and, apart from antibody testing, is probably the commonest immune test available to clinicians. It is clear that simple enumeration of uterine NK cells by immunohistochemistry is inadequate, although better methodology such as flow cytometry may prove to be more beneficial in the future. Blood testing is an appealing noninvasive test that may be a marker for immune dysfunction, rather than a guide to uterine numbers per se. It is currently performed in women with repeated reproductive failure and should be done using tests of activation. Patients value investigation and clinicians should prefer it to blind empirical immune therapy in repeated reproductive failure cases. But, in addition to blood NK testing, a fundamental new NK genetic test (the KIR/HLA‐C interaction) is likely to provide an even more effective diagnostic tool. Insights from KIR/HLA‐C analysis imply that new immune therapy trials will need to take KIR/HLA‐C results into account.

中文翻译:

自然杀伤细胞和繁殖成功。

自然杀伤 (NK) 细胞评估自 1990 年代以来一直在尝试,除了抗体测试外,它可能是临床医生可用的最常见的免疫测试。很明显,通过免疫组织化学对子宫 NK 细胞进行简单计数是不够的,尽管更好的方法如流式细胞术在未来可能会被证明更有益。血液检测是一种吸引人的无创检测,可能是免疫功能障碍的标志,而不是子宫数量本身的指南。它目前在反复生殖失败的女性身上进行,应该使用激活测试来完成。患者重视调查,临床医生应该更喜欢在反复生殖失败的情况下盲目的经验性免疫治疗。但是,除了血液NK检测,一项基本的新 NK 基因测试(KIR/HLA-C 相互作用)可能会提供更有效的诊断工具。来自 KIR/HLA-C 分析的见解意味着新的免疫疗法试验将需要考虑 KIR/HLA-C 结果。
更新日期:2020-07-02
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