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Allograft Inflammatory Factor AIF-1: early immune response in the Mediterranean sea urchin Paracentrotus lividus
Zoology ( IF 2 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.zool.2020.125815
Marco Chiaramonte 1 , Vincenzo Arizza 1 , Simona La Rosa 1 , Vinicius Queiroz 2 , Manuela Mauro 1 , Mirella Vazzana 1 , Luigi Inguglia 1
Affiliation  

Echinoderms are a phylum of deuterostomic invertebrates that play a key role in maintaining the biodiversity of marine ecosystems. They represent a good study model for immunity because their coelomic fluid contains different types of cells involved in the inflammatory response: the coelomocytes. In the case of the sea urchin Paracentrotus lividus, the coelomocyte population is mainly represented by amoebocytes and uncoloured spherulocytes that implement a defence program through phagocytosis, encapsulation, cytotoxicity, and production of antimicrobial agents. The purpose of this study was to find evidence of a possible modulating effect of lipopolysaccharide LPS on the expression of the AIF-1 gene and therefore to determine whether or not there is a correlation between the P. lividus immune response and the expression of this gene when the homeostasis of the animals is disturbed by a bacterial infection which, in this case, was simulated with treatment with LPS. AIF-1 (Allograft Inflammatory Factor 1) is a 17 kDa calcium-binding protein that, in vertebrates, is involved in the activation of macrophages. Similarly, in Echinoids and in general in invertebrates, the expression of this gene increases considerably after a bacterial attack and this suggests that it plays a key role during the immune responses.

中文翻译:

同种异体炎症因子 AIF-1:地中海海胆 Paracentrotus lividus 的早期免疫反应

棘皮动物是后口无脊椎动物的门,在维持海洋生态系统的生物多样性方面发挥着关键作用。它们代表了一种很好的免疫研究模型,因为它们的体腔液包含参与炎症反应的不同类型的细胞:体腔细胞。在海胆 Paracentrotus lividus 的情况下,体腔细胞群主要由变形细胞和无色球状细胞代表,它们通过吞噬作用、封装、细胞毒性和抗微生物剂的产生来实施防御程序。本研究的目的是寻找脂多糖 LPS 对 AIF-1 基因表达可能具有调节作用的证据,从而确定 P. 当动物的体内平衡受到细菌感染干扰时,lividus 免疫反应和该基因的表达,在这种情况下,用 LPS 治疗模拟。AIF-1(同种异体炎症因子 1)是一种 17 kDa 的钙结合蛋白,在脊椎动物中参与巨噬细胞的活化。类似地,在海胆类动物和一般无脊椎动物中,该基因的表达在细菌攻击后显着增加,这表明它在免疫反应过程中起着关键作用。
更新日期:2020-10-01
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