Two major health crisis of today's world are antimicrobial drug resistance and type II diabetes. To tackle them, there is an immediate requirement for the development of new and safer drugs and the present work is one such quest for novel and efficient drug candidates. We have developed three trace metal coordination compounds tethered with a reduced salen ligand {H₂(hpdbal)₂-an} (L), namely, a manganese-salan complex, [Mn^II(H₂O)₂{(hpdbal)₂-an}] (1), a nickel-salan complex, [Ni^II{(hpdbal)₂-an}] (2) and a copper-salan complex, [Cu^II{(hpdbal)₂-an}] (3). The compounds were characterized by elemental analysis, vibrational spectroscopy, electronic spectroscopy, thermogravimetric analysis, nuclear magnetic resonance and electron-paramagnetic resonance techniques. The compounds were evaluated for antimicrobial activity against seven pathogens (Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans and Cryptococcus neoformans) and antidiabetic activity by mimicking diabetic environment on the immortal human liver cancer cells, HepG2. Complexes 1 and 2 were additionally tested for their reactivity and stability in biological media mimic conditions. The nickel(II) salan complex (2) exhibited noteworthy antifungal activity against Candida albicans and the manganese(II) salan complex (1) induced increased glucose uptake by the insulin resistant cells. Both compounds were found to be stable when solution pH conditions were varied from 3 to 9. They exhibited strong affinity of binding towards a carrier protein, bovine serum albumin which was evaluated with the aid of multi-spectroscopic techniques.

当今世界，两大健康危机是抗菌药物耐药性和II型糖尿病。为了解决这些问题，迫切需要开发新的和更安全的药物，而目前的工作就是对新型和高效药物候选者的一种追求。我们已经开发了三种与还原的萨伦配体{H ₂（hpdbal）₂ -an}（L）系在一起的痕量金属配位化合物，即锰-铝络合物[Mn ^II（H ₂ O）₂ {（hpdbal）₂ -an}]（1），镍-铝络合物[Ni ^II {（hpdbal）₂ -an}]（2）和铜-铝络合物[Cu ^II{（hpdbal）₂ -an}]（3）。通过元素分析，振动光谱，电子光谱，热重分析，核磁共振和电子顺磁共振技术对化合物进行表征。通过在人体肝癌上模拟糖尿病肝环境，通过在人体上模拟糖尿病肝环境，评估了这些化合物对7种病原体（大肠杆菌，肺炎克雷伯菌，鲍曼不动杆菌，铜绿假单胞菌，金黄色葡萄球菌，白色念珠菌和新隐球菌）的抗菌活性以及抗糖尿病活性。配合物1还测试了2和3在生物介质模拟条件下的反应性和稳定性。镍（II）salan复合物（2）对白念珠菌具有显着的抗真菌活性，锰（II）salan复合物（1）诱导胰岛素抵抗性细胞摄取更多的葡萄糖。当溶液的pH条件从3变为9时，发现这两种化合物都是稳定的。它们对载体蛋白（牛血清白蛋白）具有很强的结合亲和力，可以通过多光谱技术对其进行评估。