Abstract In the present study, essential oils extracted from the leafy stems of Ocimum basilicum (Family Lamiaceae) and Pulicaria undulata (Family Asteraceae) were investigated for their chemical profiles and biological activity including antioxidant, antiproliferative and enzyme inhibition activities. The chemical composition of essential oil was determined using Gas Chromatography-Mass Spectrometry. The antioxidant capacity was tested by scavenging of free radicals, reduction potential, chelating ability on ferrous ions and phosphomolybdenum assays. Cell viability was evaluated on human breast carcinoma (MCF7) and human colon adenocarcinoma (HT29 and HCT116) cell lines. Enzymatic activity was evaluated against α-glucosidase, α-amylase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Based on the results obtained, in silico studies was performed to identify potential inhibitor of tyrosinase activity. Results showed that oil of O. basilicum was predominantly composed of methyl chavicol (51.9%) followed by linalool (20.0%). Oil of P. undulata was represented by oxygenated monoterpenes (96.9%) with carvotanacetone (92.1%) as the main molecule. Both oils exerted antioxidant activities with oil from P. undulata exerted significant (p

中文翻译：

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Ocimum basilicum L. 和 Pulicaria undulata (L.) CA Mey 的化学特征、抗增殖、抗氧化和酶抑制活性。生长在苏丹

摘要 在本研究中，研究了从罗勒（唇形科）和蒲公英（菊科）的叶茎中提取的精油的化学特征和生物活性，包括抗氧化、抗增殖和酶抑制活性。使用气相色谱-质谱法测定精油的化学成分。通过清除自由基、还原电位、对亚铁离子的螯合能力和磷钼测定来测试抗氧化能力。在人乳腺癌 (MCF7) 和人结肠腺癌 (HT29 和 HCT116) 细胞系上评估细胞活力。针对 α-葡萄糖苷酶、α-淀粉酶、乙酰胆碱酯酶、丁酰胆碱酯酶和酪氨酸酶评估酶活性。根据获得的结果，进行了计算机模拟研究以鉴定酪氨酸酶活性的潜在抑制剂。结果表明，O. basilicum 的油主要由甲基胡椒酚 (51.9%) 和芳樟醇 (20.0%) 组成。P. undulata 油以含氧单萜 (96.9%) 为代表，以香芹酮 (92.1%) 为主要分子。两种油都发挥了抗氧化活性，其中波峰松的油发挥了显着（p