Fumarylacetoacetate hydrolase (FAH) superfamily members are commonly expressed in the prokaryotic kingdom, where they take part in the committing steps of degradation pathways of complex carbon sources. Besides FAH itself, the only described FAH superfamily members in the eukaryotic kingdom are fumarylacetoacetate hydrolase domain containing proteins (FAHD) 1 and 2, that have been a focus of recent work in aging research. Here, we provide a review of current knowledge on FAHD proteins. Of those, FAHD1 has recently been described as a regulator of mitochondrial function and senescence, in the context of mitochondrial dysfunction associated senescence (MiDAS). This work further describes data based on bioinformatics analysis, 3D structure comparison and sequence alignment, that suggests a putative role of FAHD proteins as calcium binding proteins.

延胡索酰乙酰乙酸水解酶(FAH) 超家族成员通常在原核生物界表达，在那里它们参与复杂碳源降解途径的实施步骤。除了 FAH 本身，真核生物界中唯一描述的 FAH 超家族成员是含有延胡索酰乙酰乙酸水解酶结构域的蛋白质(FAHD) 1 和 2，这是最近衰老研究工作的重点。在这里，我们提供了关于 FAHD 蛋白质的当前知识的回顾。其中，在线粒体功能障碍相关衰老 (MiDAS) 的背景下，FAHD1 最近被描述为线粒体功能和衰老的调节剂。这项工作进一步描述了基于生物信息学分析、3D 结构比较和序列比对的数据，这表明 FAHD 蛋白作为钙结合蛋白的推定作用。