Abstract Co-precipitation of ferrous and ferric ions is the most common approach for synthesis of superparamagnetic iron oxide nanoparticles (SPIONs). However, reducing the amount of applied chemicals could lessen toxicity risks for biomedical applications. This study aimed to apply the high oxidation vulnerability of ferrous ions for synthesis of SPIONs via a single-precursor route in varied oxidative conditions. The obtained results indicated that physicochemical and magnetic properties of SPIONs were purposefully tunable through alteration of oxidative conditions and the optimized SPIONs were produced when the O2:N2 flow ratio adjusted to 5:5 in synthesis environment. The induction heating efficiency of the optimal SPIONs with different concentrations was evaluated under exposure of various alternating magnetic field (AMF). The cytotoxic activity of these SPIONs on human liver carcinoma (HepG2) cells under hyperthermia condition indicated a noticeable reduction in cell viability to 49 ± 0.3 %, rendering these magnetic nano-heating agents as promising candidates for cancer therapy purposes.

中文翻译：

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使用单独的前体用于热疗的超顺磁性氧化铁纳米颗粒的合成和体外表征

摘要 亚铁离子和三价铁离子的共沉淀是合成超顺磁性氧化铁纳米粒子 (SPIONs) 的最常用方法。然而，减少应用化学品的数量可以降低生物医学应用的毒性风险。本研究旨在利用亚铁离子的高氧化脆弱性，在各种氧化条件下通过单一前体途径合成 SPION。所得结果表明，SPIONs的理化和磁性能可以通过改变氧化条件有目的地调节，当合成环境中O2:N2流量比调整为5:5时，产生了优化的SPIONs。在各种交变磁场 (AMF) 暴露下评估了不同浓度的最佳 SPION 的感应加热效率。