As an important reactive carbonyl compound, formaldehyde (FA) existing in various parts of the organism and plays an important role in cognitive ability and memory formation. However, abnormal concentrations of FA could cause many diseases. Herein, a novel 1,8-naphthalimide derivative fluorescent probe (NID) for detecting FA was rationally designed and synthesized. Probe NID showed a rapid response (within 8 s) towards FA with visual detection. More importantly, NID can be used to image FA in MCF-7 cells, which demonstrated its suitability for practical applications of biological systems with low cytotoxicity.

中文翻译：

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基于1，8-萘二甲酰亚胺衍生物的新型甲醛荧光探针及其在活细胞中的应用

作为重要的反应性羰基化合物，甲醛（FA）存在于生物体的各个部位，并在认知能力和记忆形成中起重要作用。但是，FA的异常浓度可能导致许多疾病。在这里，合理地设计和合成了一种新型的1,8-萘二甲酰亚胺衍生物荧光探针（NID）。NID探针通过视觉检测显示出对FA的快速响应（8秒钟内）。更重要的是，NID可用于对MCF-7细胞中的FA成像，这证明了其适用于低细胞毒性生物系统的实际应用。