Personal care and consumer products are extensively used and contain various chemicals that are recognized as endocrine disrupting chemicals. Few epidemiological studies measured the associations of these chemicals and metabolites, especially phenols, with bone health. We measured the associations between nine urinary phenol biomarkers and BMD and the subsequent prevalence of osteopenia/osteoporosis. National representative data from US adults aged over 20 years who participated in the National Health and Nutrition Examination Survey from 2005 to 2010 were used. 2,267 men, 1,145 premenopausal women and 1,033 postmenopausal women were included in the final analyses. Bisphenol A, benzophenone-3, triclosan, butylparaben, ethylparaben, methylparaben, propylparaben, 2,5-dichlorophenol and 2,4-dichlorophenol were measured by high-performance liquid chromatography-isotope dilution tandem mass spectrometry. Paraben concentrations, especially ethyl-, methyl- and propylparabens, were related to greater BMD in the femoral neck and intertrochanter and lumbar spine in men and premenopausal women. 2,4-dichlorophenol concentrations was associated with lower BMD and a higher prevalence of osteopenia + osteoporosis in men. Bisphenol A was associated with a higher prevalence of osteopenia + osteoporosis in the lumbar spine in postmenopausal women. Benzophenone-3 tended to be associated with a higher BMD of femur in men and premenopausal women. In conclusion, certain urinary personal care and consumer product chemicals and metabolites were significantly associated with BMD or osteopenia + osteoporosis. These results further indicate that, in future research, determination of the causal relationships and detection of undelying mechanism could be next important directions.

个人护理和消费产品被广泛使用，并且包含各种被认为是破坏内分泌的化学物质。很少有流行病学研究测量这些化学物质和代谢产物（尤其是酚）与骨骼健康的关系。我们测量了九种尿酚生物标志物和骨密度之间的联系以及随后的骨质减少/骨质疏松症的患病率。使用了来自2005年至2010年参加美国国家健康和营养检查调查的20岁以上美国成年人的国家代表性数据。最终分析包括2267例男性，1145例绝经前的女性和1033例绝经后的女性。双酚A，二苯甲酮3，三氯生，对羟基苯甲酸丁酯，对羟基苯甲酸乙酯，对羟基苯甲酸甲酯，对羟基苯甲酸丙酯，2,5-二氯苯酚和2，通过高效液相色谱-同位素稀释串联质谱法测量4-二氯苯酚。对羟基苯甲酸酯的浓度，尤其是对羟基苯甲酸乙酯，对羟基苯甲酸甲酯，对羟基苯甲酸甲酯和对羟基苯甲酸丙酯的浓度与男性和绝经前女性股骨颈，转子间和腰椎的BMD升高有关。2,4-二氯苯酚浓度与较低的BMD和较高的男性骨质疏松症+骨质疏松症患病率有关。双酚A与绝经后妇女腰椎骨质疏松症+骨质疏松症的患病率较高相关。在男性和绝经前女性中，苯甲酮3往往与较高的股骨BMD有关。总之，某些尿液个人护理和消费品化学物质及代谢产物与BMD或骨质减少+骨质疏松症显着相关。这些结果进一步表明，