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Determining the burden of infectious diseases caused by carbapenem-resistant gram-negative bacteria in Spain
Enfermedades Infecciosas y Microbiología Clínica ( IF 2.5 ) Pub Date : 2020-06-21 , DOI: 10.1016/j.eimc.2020.04.009
Rafael Cantón 1 , Rafael Huarte 2 , Laura Morata 3 , José Luís Trillo-Mata 4 , Rocío Muñoz 5 , Javier González 5 , Marina Tort 6 , Xavier Badia 6
Affiliation  

Objective

To estimate the burden of nosocomial infections induced by carbapenem resistant Gram-negative (CRGN) pathogens in Spain, focusing on both the clinical and economic impact.

Methods

The burden of disease was estimated using data from 2017 according to the availability of data sources. The impact, both clinical and economic, of the most frequent CRGN nosocomial infections (those produced by Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii) was analysed. Incidence and mortality of CRGN nosocomial infections were estimated, as well as the direct and indirect costs produced by this health problem.

Results

Approximately 376,346 patients are believed to have suffered a nosocomial infection in Spain in 2017; 3.2% of them due to CRGN bacilli. Infections by carbapenem-resistant P. aeruginosa produced the highest mortality rates (2578 deaths) when compared with A. baumannii (1571) and K. pneumoniae (415). Total economic costs of CRGN nosocomial infections in Spain were estimated to be €472 million in 2017, with 83% of the total cost caused by direct costs.

Conclusion

CRGN nosocomial infections have a high clinical impact on patients’ lives, high mortality rates, and represent one of the hospitalisation episodes with the most associated costs. Efforts should be focussed to implement preventive policies in order to avoid infections due to CRGN pathogens and the resulting burden, and to reduce direct costs due to morbimortality, specifically in those infections produced by P. aeruginosa.



中文翻译:

确定西班牙耐碳青霉烯革兰氏阴性菌引起的传染病负担

客观的

评估西班牙耐碳青霉烯革兰氏阴性 (CRGN) 病原体引起的医院感染负担,重点关注临床和经济影响。

方法

根据数据来源的可用性,使用 2017 年的数据估算了疾病负担。分析了最常见的 CRGN 医院感染(由肺炎克雷伯菌、铜绿 假单胞菌鲍曼不动杆菌产生的感染)的临床和经济影响。估计了 CRGN 医院感染的发生率和死亡率,以及由该健康问题产生的直接和间接成本。

结果

据信,2017 年西班牙约有 376,346 名患者遭受了院内感染;其中 3.2% 是由于 CRGN 杆菌。与鲍曼不动杆菌(1571) 和肺炎克雷伯菌(415)相比,耐碳青霉烯铜绿假单胞菌感染的死亡率最高(2578 人死亡)。2017 年西班牙 CRGN 医院感染的总经济成本估计为 4.72 亿欧元,其中 83% 的总成本由直接成本引起。

结论

CRGN 医院感染对患者的生活有很大的临床影响,死亡率很高,并且是相关费用最高的住院事件之一。应重点努力实施预防政策,以避免因 CRGN 病原体引起的感染和由此产生的负担,并减少因病死率引起的直接成本,特别是在铜绿假单胞菌产生的感染中。

更新日期:2020-06-21
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