High-resolution cell patterning technology is a versatile tool for studying tissue engineering and in vitro preclinical research, but simple methods that can be implemented easily are lacking. Here, we demonstrate a simple electrochemical approach for arranging cells into various patterns, enabling rapid and accurate localization for cell array formation. A voltage pulse is applied directly to the pre-patterned conducting substrate, causing cellular damage and rapidly forming live/dead cell arrays. The array platform, which focuses on assay miniaturization, is applicable to cell-based drug screening as well as high-content cell culture experiments.

中文翻译：

---

电化学活细胞图案

高分辨率细胞构图技术是研究组织工程和体外临床前研究的多功能工具，但是缺少易于实施的简单方法。在这里，我们演示了一种简单的电化学方法，可将细胞排列成各种模式，从而能够快速准确地定位细胞阵列。将电压脉冲直接施加到预先构图的导电基板上，导致细胞损伤并迅速形成活/死细胞阵列。专注于测定小型化的阵列平台适用于基于细胞的药物筛选以及高含量的细胞培养实验。