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Difficult-to-treat pathogens significantly reduce infection resolution in periprosthetic joint infections.
Diagnostic Microbiology and Infectious Disease ( IF 2.9 ) Pub Date : 2020-06-20 , DOI: 10.1016/j.diagmicrobio.2020.115114
Matthias D Wimmer 1 , Gunnar T R Hischebeth 2 , Thomas M Randau 1 , Martin Gathen 1 , Frank A Schildberg 1 , Frank S Fröschen 1 , Hendrik Kohlhof 1 , Sascha Gravius 3
Affiliation  

Periprosthetic joint infection (PJI) is a feared complication after arthroplasty. Our hypothesis was that PJI caused by difficult-to-treat (DTT) pathogens has a worse outcome compared with non-DTT PJI.

Routine clinical data on 77 consecutive patients with confirmed PJI treated with two-stage exchange arthroplasty were placed in DTT and non-DTT PJI groups and analyzed. The main outcome variable was that the patient was definitively free of infection after two years.

We found definitive infection resolution in 31 patients in the DTT group (68.9%) and 28 patients (87.5%) in the non-DTT group (p < 0.05). The necessity for revision surgery until assumed resolution of infection was significantly more frequent in the DTT group with 4.72 ± 3.03 operations vs. 2.41 ± 3.02 operations in the non-DTT group (p < 0.05).

PJI caused by DTT bacteria is associated with significantly higher numbers of revision operations and significantly inferior definitive infection resolution.



中文翻译:

难以治疗的病原体会大大降低假体周围关节感染的感染分辨率。

假体周围关节感染(PJI)是关节置换术后令人恐惧的并发症。我们的假设是,与非DTT PJI相比,由难以治疗(DTT)病原体引起的PJI的结局更差。

将连续两阶段置换置换术治疗的77例PJI确诊患者的常规临床数据分为DTT组和非DTT PJI组,并进行分析。主要结果变量是患者在两年后一定没有感染。

我们发现DTT组的31例患者(68.9%)和非DTT组的28例(87.5%)的确诊感染消退(p <0.05)。DTT组进行4.72±3.03次手术之前,必须进行翻修手术直至达到假定的感染消退,而非DTT组为2.41±3.02次手术(p <0.05)。

由DTT细菌引起的PJI与明显更高的翻版操作次数和明显较差的确定感染分辨率相关。

更新日期:2020-06-22
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