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Intron Retained, Transcript Detained: Intron Retention as a Hallmark of the Quiescent Satellite Cell State.
Developmental Cell ( IF 11.8 ) Pub Date : 2020-06-22 , DOI: 10.1016/j.devcel.2020.05.028
Kiran Nakka 1 , Radmila Kovac 1 , Matthew Man-Kin Wong 1 , F Jeffrey Dilworth 2
Affiliation  

Molecular signatures defining quiescence in muscle satellite cells (mSCs) remain enigmatic. In this issue of Developmental Cell, Yue et al. adapted an in vivo fixation approach to isolate dormant mSCs from healthy muscle. Characterizing the transcriptome from these cells, they identified intron retention as a novel hallmark of mSC quiescence.



中文翻译:

内含子保留,转录本被保留:内含子保留是静态卫星细胞状态的标志。

定义肌肉卫星细胞(mSCs)静止的分子标记仍然是个谜。在本期《发育细胞》中,Yue等人。修改了体内固定方法以从健康肌肉中分离出休眠的mSC。他们表征了这些细胞的转录组,确定内含子保留是mSC静止的新标志。

更新日期:2020-06-22
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