Cofactor F₄₂₀ is historically known as the methanogenic redox cofactor, having a key role in the central metabolism of methanogens, and archaea in general. Over the past decade, however, it has become evident this cofactor is more widely distributed across archaeal and bacterial taxa, suggesting a broader role for F₄₂₀ in various metabolic and ecological capacities. In this article, we focus on the recent findings that have led to a deeper understanding of F₄₂₀ biosynthetic enzymes and metabolites across microorganisms.

中文翻译：

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多功能辅因子 F420 生物合成的收敛途径。

辅因子 F ₄₂₀在历史上被称为产甲烷氧化还原辅因子，在产甲烷菌和一般古细菌的中心代谢中具有关键作用。然而，在过去十年中，很明显这种辅助因子更广泛地分布在古菌和细菌类群中，表明 F ₄₂₀在各种代谢和生态能力中发挥着更广泛的作用。在本文中，我们关注最近的发现，这些发现有助于更深入地了解微生物中的 F ₄₂₀生物合成酶和代谢物。