Microbial cell factory performance is significantly affected by the cell morphology and membrane homeostasis. It is important to ensure that cell factories are able to regulate cell morphology and maintain membrane homeostasis. Cell morphology can be controlled by regulating the formation of elongasomes and divisomes, which change the shapes of cells from rods to fibers, large spheres, or mini-cells. Membrane homeostasis can also be controlled by regulating the homeostasis of membrane lipids and proteins, thereby improving the robustness of microbes in toxic environments. In the present review, we discuss promising developments in cell morphology and membrane homeostasis engineering that have improved microbial cell factory performance.

微生物细胞的出厂性能受细胞形态和膜稳态的影响很大。确保细胞工厂能够调节细胞形态并维持膜稳态非常重要。细胞形态可以通过调节伸长体和分裂体的形成来控制，这些改变将细胞的形状从杆状变为纤维状，大球形或小细胞。膜稳态也可以通过调节膜脂质和蛋白质的稳态来控制，从而提高了微生物在有毒环境中的健壮性。在当前的审查中，我们讨论细胞形态和膜稳态工程中有望改善微生物细胞工厂性能的发展。