Atopic dermatitis (AD) lesional skin is often colonized with S. aureus, and the load of S. aureus correlates with disease severity. However, a causative and mechanistic link between S. aureus skin colonization and severity of AD is not well established. We made use of well-established mouse model of AD elicited by epicutaneous sensitization of tape stripped skin with ovalbumin to investigate the relationship between allergic skin inflammation and cutaneous S. aureus colonization. Topical application of S aureus exacerbated allergic skin inflammation induced by epicutaneous sensitization with ovalbumin, whereas allergic skin inflammation generated a permissive environment for S. aureus persistence. Our results establish a mutually reinforcing role of allergic skin inflammation and S. aureus skin colonization.

特应性皮炎（AD）的病变皮肤经常与定植金黄色葡萄球菌，和的负载金黄色葡萄球菌相关因素与疾病严重程度。然而，金黄色葡萄球菌皮肤定植与 AD 严重程度之间的因果关系和机制尚未完全确定。我们利用通过用卵清蛋白对胶带剥离的皮肤进行表皮致敏引起的成熟的 AD 小鼠模型来研究过敏性皮肤炎症与皮肤金黄色葡萄球菌定植之间的关系。金黄色葡萄球菌的局部应用加剧了由卵清蛋白表皮致敏引起的过敏性皮肤炎症，而过敏性皮肤炎症为金黄色葡萄球菌产生了一个允许的环境坚持。我们的结果确立了过敏性皮肤炎症和金黄色葡萄球菌皮肤定植的相互促进作用。