OBJECTIVE To compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) combined with strengthening and stretching exercises in patients with fibromyalgia. DESIGN Interventional, single-blinded, randomized-controlled trial. SETTING Outpatient rehabilitation center. PARTICIPANTS Sixty women diagnosed with fibromyalgia were randomized to HIIT, MICT and Control groups. INTERVENTIONS HIIT included a 5-min warm-up at 50% of peak-HR, four cycles of 4-min at 80-95% of peak-HR followed by 3-min recovery intervals at 70% of peak-HR. MICT consisted of 45-min at 65-70% of peak-HR. Each aerobic training session was followed by standardized strengthening and stretching exercises. The programs performed using cycle-ergometers 5-sessions per-week for 6-weeks. The control group did not participate in any supervised exercise sessions. MAIN OUTCOME MEASURES The primary outcome measure was the Fibromyalgia Impact Questionnaire (FIQ). The secondary outcome measures were visual analogic scale for pain, Short Form Health Survey-36 (SF-36), cardiopulmonary exercise test (CPET) and body composition parameters. RESULTS Fifty-five participants completed the study. There was no significant difference in FIQ between HIIT vs MICT (1.03; 95% confidence interval (CI) -9.67 to 11.75) after treatment. Group-time interactions were significant for the FIQ between interventions and control (HIIT vs Control -16.20; 95% CI -27.23 to -5.13 and MICT vs Control -17.24; 95% CI -28.27 to -6.22) (all P<0.001). There were significant group-time interactions for the pain, SF-36 and CPET parameters between treatments and control (all P<0.05). Body-weight, fat-percentage, fat-mass and body mass index improved significantly (all P<0.05) only in MICT group after treatment. CONCLUSIONS The HIIT plus strengthening and stretching exercises and MICT plus strengthening and stretching exercises interventions showed significant improvements for the impact of fibromyalgia, pain degree, functional capacity and quality of life compared to the control group. HIIT was not superior to MICT. Furthermore, body composition parameters were improved significantly only for the MICT.

中文翻译：

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高强度间歇训练与中等强度持续训练对纤维肌痛患者的有效性：一项初步随机对照试验

目的比较高强度间歇训练（HIIT）和中等强度持续训练（MICT）结合力量和伸展运动对纤维肌痛患者的影响。设计 干预性、单盲、随机对照试验。设置门诊康复中心。参与者 60 名被诊断患有纤维肌痛的女性被随机分配到 HIIT、MICT 和对照组。干预措施 HIIT 包括在峰值 HR 的 50% 时进行 5 分钟的热身，在峰值 HR 的 80-95% 时进行 4 分钟的四个循环，然后在峰值 HR 的 70% 时进行 3 分钟的恢复间隔。MICT 包括 45 分钟，峰值 HR 的 65-70%。每次有氧训练后，都会进行标准化的力量训练和伸展运动。这些程序使用自行车测力计每周 5 次，持续 6 周。对照组不参加任何有监督的锻炼课程。主要结局指标 主要结局指标是纤维肌痛影响问卷 (FIQ)。次要结果测量是疼痛的视觉类比量表、简短健康调查 - 36 (SF-36)、心肺运动测试 (CPET) 和身体成分参数。结果 55 名参与者完成了这项研究。治疗后 HIIT 与 MICT 之间的 FIQ 无显着差异（1.03；95% 置信区间 (CI) -9.67 至 11.75）。组间交互对干预和对照之间的 FIQ 具有显着意义（HIIT 与对照 -16.20；95% CI -27.23 至 -5.13 和 MICT 与对照 -17.24；95% CI -28.27 至 -6.22）（所有 P <0.001） . 疼痛有显着的小组时间相互作用，治疗组和对照组之间的SF-36和CPET参数（均P<0.05）。仅MICT组治疗后体重、脂肪百分比、脂肪量和体重指数显着改善（均P<0.05）。结论 与对照组相比，HIIT 加力量和伸展运动和 MICT 加力量和伸展运动干预对纤维肌痛、疼痛程度、功能能力和生活质量的影响有显着改善。HIIT 并不优于 MICT。此外，仅 MICT 的身体成分参数得到显着改善。结论 与对照组相比，HIIT 加强化和伸展运动和 MICT 加强化和伸展运动干预在纤维肌痛的影响、疼痛程度、功能能力和生活质量方面均显着改善。HIIT 并不优于 MICT。此外，仅 MICT 的身体成分参数得到显着改善。结论 与对照组相比，HIIT 加力量和伸展运动和 MICT 加力量和伸展运动干预对纤维肌痛、疼痛程度、功能能力和生活质量的影响有显着改善。HIIT 并不优于 MICT。此外，仅 MICT 的身体成分参数得到显着改善。