Menopause is a major factor involved in dyslipidemia increasing the risk of atherosclerosis which may be reversed by a routine of aerobic physical activity. Thus, this study aimed to analyze the effects of aerobic training on the thoracic aorta of female LDL-receptor knockout mice submitted to estrogen deprivation. Fifteen genetically modified female mice, knockout for the low-density lipoprotein receptor (LDL-Knockout group) were used as experimental groups and fifteen wild female mice (C57BL/6 J) were used as control groups. Animals were divided as (n = 5/per group): sedentary control (SC); sedentary control ovariectomized (SCO); trained control ovariectomized (TCO); LDL-Knockout sedentary (KS); LDL-Knockout sedentary ovariectomized (KOS); and LDL-Knockout trained ovariectomized (KOT). Immunohistochemical techniques for TIMP-1 and metalloproteinases 2 and 9 were used to evaluate thoracic aorta remodeling. Picrosirius stain was used to highlight the collagen fibers. Verhoff-Van Gienson was used for the quantitative analyses of elastic lamellae. Our results demonstrate a positive remodeling promoted by physical exercise in ovariectomized and dyslipidemic animals. However, further studies are needed including the evaluation of inflammatory markers present in dyslipidemia.

绝经是血脂异常的主要因素，增加了动脉粥样硬化的风险，这可以通过常规的有氧体育锻炼来逆转。因此，本研究旨在分析有氧训练对雌激素剥夺的雌性LDL受体敲除小鼠胸主动脉的影响。将十五只转基因雌性小鼠，低密度脂蛋白受体基因敲除组（LDL-敲除组）用作实验组，并将十五只野生雌性小鼠（C57BL / 6 J）用作对照组。将动物分为（n ＝ 5 /每组）：久坐对照（SC）；久坐对照（SC）。久坐控制切除卵巢（SCO）; 训练有素的卵巢切除术（TCO）；LDL淘汰久坐（KS）; LDL-基因敲除久坐卵巢切除术（KOS）；和LDL-Knockout训练的去卵巢（KOT）。TIMP-1和金属蛋白酶2和9的免疫组织化学技术用于评估胸主动脉重塑。Picrosirius染色用于突出胶原纤维。Verhoff-Van Gienson用于弹性薄片的定量分析。我们的研究结果表明，体育锻炼可促进卵巢切除和血脂异常动物的积极重塑。但是，还需要进一步的研究，包括评估血脂异常中存在的炎症标志物。