Abstract

It was found that the substitution of electoneutral dioleoylphosphatidylcholine with dipalmytoylphosphatidylcholine in membrane of anionic fliposomes with molar fraction of pH-sensitive 4,5-bis-dodecylcarbonyl-2-morpholincyclohexanol 0.3 does not result in formation of expected gel-state liposomes. Nevertheless, this change in composition of lipid membrane strongly affects on kinetics of pH-governed release of incapsulated in fliposomes salt.

中文翻译：

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中性脂质性质对pH调节阴离子脂质体中盐释放的意外影响

摘要

已经发现，用pH敏感的4,5-双十二烷基羰基-2-吗啉环己醇0.3的摩尔分数用阴离子型脂质体膜中的二巯基酰基磷脂酰胆碱代替电子琴油醇二磷酸磷脂酰胆碱不会导致形成预期的凝胶态脂质体。然而，脂质膜组成的这种变化强烈影响着pH值控制的脂质体盐胶囊的释放动力学。