Abstract This review analyzes and summarizes some actual models of raft organization as dynamic structural units in lipid membranes emphasizing the discrimination between mechanisms influencing raft nanodomain formation and maintenance in biological and model membranes on one hand and the roles of membrane proteins on the other. The contentious issue of specific input of cholesterol recognizing/interacting amino acid consensus (CRAC) motifs in the membrane rafts and protein interaction mechanism at the molecular level is discussed in detail. Especially, lipid membrane raft-like structure of some enveloped viruses is considered as a manifest example demonstrating the basic organization of raft-type membranes.

中文翻译：

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生物膜中筏状组织的分子机制

摘要 本综述分析和总结了作为脂质膜中动态结构单元的筏组织的一些实际模型，强调一方面区分影响生物膜和模型膜中筏纳米域形成和维持的机制，另一方面强调膜蛋白的作用。在分子水平上详细讨论了膜筏中胆固醇识别/相互作用氨基酸共有 (CRAC) 基序的特定输入和蛋白质相互作用机制的争议问题。特别是，一些包膜病毒的脂膜筏状结构被认为是证明筏型膜基本组织的一个明显例子。