Abstract — The aim of this work was to evaluate novel three-domain antibodies consisting of two domains specific for human tumor necrosis factor (hTNF), and of the third domain responsible for binding to myeloid cells. The additional hTNF-binding domain should serve to increase the biological activity of new antibodies. Capacity of these proteins to bind hTNF on the macrophage surface and to neutralize its biological activity in vitro was assessed.

中文翻译：

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抗肿瘤坏死因子的三域抗体：体外生物学活性研究

摘要 — 这项工作的目的是评估新型三域抗体，该抗体由两个对人肿瘤坏死因子 (hTNF) 特异的域和负责与骨髓细胞结合的第三个域组成。额外的 hTNF 结合域应该用于增加新抗体的生物活性。评估了这些蛋白质在巨噬细胞表面结合 hTNF 并在体外中和其生物活性的能力。