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LncRNAs and circular RNAs as endothelial cell messengers in hypertension: mechanism insights and therapeutic potential.
Molecular Biology Reports ( IF 2.8 ) Pub Date : 2020-06-21 , DOI: 10.1007/s11033-020-05601-5
Ji-Ru Zhang 1 , Hai-Jian Sun 2, 3
Affiliation  

Endothelial cells are major constituents in the vasculature, and they act as important players in vascular homeostasis via secretion/release of vasodilators and vasoconstrictors. In healthy arteries, endothelial cells play a key role in the regulation of vascular tone, cellular adhesion, and angiogenesis. A shift in the functions of the blood vessels toward vasoconstriction, proinflammatory state, oxidative stress and deficiency of nitric oxide (NO) might lead to endothelial dysfunction, a key event implicated in the pathophysiology of cardiovascular metabolic diseases, including diabetes, atherosclerosis, arterial hypertension and pulmonary arterial hypertension (PAH). Thus, reversibility of endothelial dysfunction may be beneficial for maintaining vascular homeostasis. In recent years, accumulative evidence has documented that noncoding RNAs (ncRNAs) are critically involved in endothelial homeostasis. Specifically, long noncoding RNAs (lncRNAs) and circular RNAs are highly expressed in endothelial cells where they serve as important mediators in normal endothelial functions. Dysregulation of lncRNAs and circular RNAs has been tightly associated with hypertension-related endothelial dysfunction. In this review, we will summarize the current progression and underlying mechanisms of lncRNA and circular RNA in endothelial cell biology under hypertensive conditions. We will also highlight their potential as biomarkers or therapeutic targets for hypertension and its associated endothelial dysfunction.



中文翻译:

LncRNA和环状RNA作为高血压内皮细胞信使:机制的见解和治疗潜力。

内皮细胞是脉管系统中的主要成分,通过血管扩张剂和血管收缩剂的分泌/释放,它们在血管稳态中起着重要的作用。在健康的动脉中,内皮细胞在调节血管紧张度,细胞粘附和血管生成中起关键作用。血管功能向血管收缩,促炎状态,氧化应激和一氧化氮缺乏的转变可能导致内皮功能障碍,这是心血管代谢疾病(包括糖尿病,动脉粥样硬化,动脉高压)的病理生理学中涉及的关键事件和肺动脉高压(PAH)。因此,内皮功能障碍的可逆性可能有利于维持血管稳态。最近几年,积累的证据表明,非编码RNA(ncRNA)关键参与内皮稳态。具体而言,长非编码RNA(lncRNA)和环状RNA在内皮细胞中高度表达,在内皮细胞中它们是正常内皮功能的重要介体。lncRNA和环状RNA的失调与高血压相关的内皮功能异常密切相关。在这篇综述中,我们将总结高血压条件下内皮细胞生物学中lncRNA和环状RNA的当前进展及其潜在机制。我们还将重点介绍它们作为高血压及其相关的内皮功能障碍的生物标志物或治疗靶标的潜力。长非编码RNA(lncRNA)和环状RNA在内皮细胞中高度表达,在内皮细胞中它们是正常内皮功能的重要介体。lncRNA和环状RNA的失调与高血压相关的内皮功能异常密切相关。在这篇综述中,我们将总结高血压条件下内皮细胞生物学中lncRNA和环状RNA的当前进展及其潜在机制。我们还将重点介绍它们作为高血压及其相关的内皮功能障碍的生物标志物或治疗靶标的潜力。长非编码RNA(lncRNA)和环状RNA在内皮细胞中高度表达,在内皮细胞中它们是正常内皮功能的重要介体。lncRNA和环状RNA的失调与高血压相关的内皮功能异常密切相关。在这篇综述中,我们将总结高血压条件下内皮细胞生物学中lncRNA和环状RNA的当前进展及其潜在机制。我们还将重点介绍它们作为高血压及其相关的内皮功能障碍的生物标志物或治疗靶标的潜力。我们将总结高血压条件下内皮细胞生物学中lncRNA和环状RNA的当前进展及其潜在机制。我们还将重点介绍它们作为高血压及其相关的内皮功能障碍的生物标志物或治疗靶标的潜力。我们将总结高血压条件下内皮细胞生物学中lncRNA和环状RNA的当前进展及其潜在机制。我们还将重点介绍它们作为高血压及其相关的内皮功能障碍的生物标志物或治疗靶标的潜力。

更新日期:2020-06-22
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