GlycA, a novel marker for low grade inflammation, reflects gut microbiome diversity and is more accurate than high sensitive CRP in reflecting metabolomic profile.,Metabolomics

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GlycA, a novel marker for low grade inflammation, reflects gut microbiome diversity and is more accurate than high sensitive CRP in reflecting metabolomic profile.
Metabolomics ( IF 3.6 ) Pub Date : 2020-06-20 , DOI: 10.1007/s11306-020-01695-x
Kati Mokkala ₁ , Noora Houttu ₁ , Ella Koivuniemi ₁ , Nikolaj Sørensen ₂ , Henrik Bjørn Nielsen ₂ , Kirsi Laitinen _{1,

3}

Affiliation

Introduction

Gut microbiota is, along with adipose tissue, recognized as a source for many metabolic and inflammatory disturbances that may contribute to the individual’s state of health.

Objectives

We investigated in cross-sectional setting the feasibility of utilizing GlycA, a novel low grade inflammatory marker, and traditional low grade inflammatory marker, high sensitivity CRP (hsCRP), in reflecting serum metabolomics status and gut microbiome diversity.

Methods

Fasting serum samples of overweight/obese pregnant women (n = 335, gestational weeks: mean 13.8) were analysed for hsCRP by immunoassay, GlycA and metabolomics status by NMR metabolomics and faecal samples for gut microbiome diversity by metagenomics. The benefits of GlycA as a metabolic marker were investigated against hsCRP.

Results

The GlycA concentration correlated with more of the metabolomics markers (144 out of 157), than hsCRP (55 out of 157) (FDR < 0.05). The results remained essentially the same when potential confounding factors known to associate with GlycA and hsCRP levels were taken into account (P < 0.05). This was attributable to the detected correlations between GlycA and the constituents and concentrations of several sized VLDL-particles and branched chain amino acids, which were statistically non-significant with regard to hsCRP. GlycA, but not hsCRP, correlated inversely with gut microbiome diversity.

Conclusion

GlycA is a superior marker than hsCRP in assessing the metabolomic profile and gut microbiome diversity. It is proposed that GlycA may act as a novel marker that reflects both the gut microbiome and adipose tissue originated metabolic aberrations; this proposal will need to be verified with regard to clinical outcomes.

Clinical trial registration

ClinicalTrials.gov, NCT01922791, August 14, 2013

中文翻译：

GlycA是低度炎症的新型标志物，可反映肠道微生物组多样性，在反映代谢组学特征方面比高敏感性CRP更准确。

介绍

肠道菌群以及脂肪组织被认为是许多新陈代谢和炎性疾病的来源，这些疾病可能有助于个体的健康状况。

目标

我们在横断面中研究了利用GlycA（一种新型的低级炎症标志物）和传统的低级炎症标志物，高灵敏度CRP（hsCRP）来反映血清代谢组学状态和肠道微生物组多样性的可行性。

方法

超重/肥胖孕妇的空腹血清样本（n = 335，孕周：平均13.8）通过免疫测定分析hsCRP，通过NMR代谢组学分析GlycA和代谢组学状态，并通过宏基因组学对粪便样本进行肠道微生物组多样性分析。研究了针对hsCRP的GlycA作为代谢指标的益处。

结果

与hsCRP（157个中的55个）相比，GlycA浓度与更多的代谢组学标记物相关（157个中的55个）（FDR <0.05）。当考虑到已知与GlycA和hsCRP水平相关的潜在混杂因素时，结果基本相同（P <0.05）。这归因于在GlycA与几种大小的VLDL颗粒和支链氨基酸的成分和浓度之间检测到的相关性，这些相关性在hsCRP方面无统计学意义。GlycA（而非hsCRP）与肠道微生物组多样性呈负相关。