The association between coronaviruses and central nervous system (CNS) demyelinating lesions has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease so far. SARS-COV-2 was previously detected in cerebrospinal fluid (CSF) sample of a patient with encephalitis. However, the virus identity was not confirmed by deep sequencing of SARS-COV-2 detected in the CSF. Here, we report a case of a patient with mild respiratory symptoms and neurological manifestations compatible with clinically isolated syndrome. The viral genome of SARS-COV-2 was detected and sequenced in CSF with 99.74–100% similarity between the patient virus and worldwide sequences. This report suggests a possible association of SARS-COV-2 infection with neurological symptoms of demyelinating disease, even in the absence of relevant upper respiratory tract infection signs.

先前已经显示了冠状病毒和中枢神经系统（CNS）脱髓鞘病变之间的关联。然而，迄今为止，尚未描述新的冠状病毒（SARS-COV-2）和CNS脱髓鞘疾病之间的关联。先前在脑炎患者的脑脊液（CSF）样本中检测到SARS-COV-2。但是，通过在CSF中检测到的SARS-COV-2的深度测序无法确认病毒的身份。在这里，我们报告了一例轻度呼吸道症状和神经系统表现与临床孤立综合征兼容的患者。检测到SARS-COV-2的病毒基因组，并在CSF中测序，患者病毒与全球序列之间有99.74–100％的相似性。