Abstract

An efficient and inexpensive method for the N-alkylation of pyrimidines using ammonium sulfate coated Hydro-Thermal-Carbone (HTC) (AS@HTC) as reused heterogeneous catalyst was developed. The catalyst was characterized by several analytical techniques such as SEM, XRD, and FTIR. The effect of various parameters was studied including catalyst loading, mole ratio, to achieve excellent selectivity and yields in 80–90%. Significantly, the present protocol offers the use of an inexpensive and environmentally friendly catalyst and simple workup. The simplicity of the procedure, excellent yield of the products, and the recyclability of the catalyst are the main advantages of this method.

Graphic Abstract

Ammonium sulfate coated Hydro-Thermal-Carbone (HTC) (AS@HTC); an efficient and reused heterogeneous catalyst of the N-alkylation of pyrimidines was developed. Excellent selectivity and yields (80–90%) toward N1-alkylpyrimidines were achieved. Significantly, the present protocol offers the use of an inexpensive and environmentally friendly catalyst and simple workup.

中文翻译：

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环保条件下硫酸铵@水热碳高效选择性催化N-烷基化嘧啶

摘要

开发了一种高效且廉价的嘧啶N-烷基化方法，该方法使用硫酸铵涂覆的水热碳化合物（HTC）（AS @ HTC）作为重复使用的非均相催化剂。通过几种分析技术，如SEM，XRD和FTIR对催化剂进行了表征。研究了各种参数的影响，包括催化剂负载量，摩尔比，以实现出色的选择性和80-90％的收率。重要的是，本方案提供了廉价且环保的催化剂的使用和简单的后处理。该方法的主要优点是操作简单，产物的产率高以及催化剂的可回收性。

图形摘要

硫酸铵涂层的水热碳纤维（HTC）（AS @ HTC）; 开发了一种高效且可重复使用的嘧啶N-烷基化的多相催化剂。对N1-烷基嘧啶具有优异的选择性和收率（80–90％）。重要的是，本方案提供了廉价且环保的催化剂的使用和简单的后处理。