Prognostic biomarkers remain a focus in breast cancer during last decades. More reliable predictors to adequately characterize the prognosis of breast cancer are essential. The 2′-5′-oligoadenylate synthetases (OAS), composing of OAS1, OAS2, OAS3, and OAS-like (OASL), are interferon (IFN)-induced antiviral enzymes, with their prognostic roles remain to be characterized. Prognostic values of OAS family members were assessed by multiple public available resources. High mRNA expression of OAS1 and OAS3 were correlated with worse prognosis for all breast cancer patients, whereas OAS2 was associated with favorable prognosis. The prognostic values of OAS family in different clinicopathologic subtypes were also characterized. In DNA methylation level, cg12560128 in OAS2, cg06800840 and cg26328872 in OASL showed significant prognostic values. The mRNA expression of OAS members signature in high/low risk overall survival groups was opposite to the high/low risk recurrence free survival groups. Neutrophil cell exhibited highest correlation with all OAS members in tumor immune infiltrating estimation. This study provided new insight into the prognostic roles of OAS in breast cancer with potential mechanistic values.

中文翻译：

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OAS1 / OAS2 / OAS3 / OASL在乳腺癌中的预后特征。

在过去的几十年中，预后性生物标志物仍然是乳腺癌的焦点。充分表征乳腺癌预后的更可靠的预测指标至关重要。由OAS1，OAS2，OAS3和类似OAS的（OASL）组成的2'-5'-寡腺苷酸合成酶（OAS）是干扰素（IFN）诱导的抗病毒酶，其预后作用尚待鉴定。OAS家庭成员的预后价值通过多种公共可用资源进行评估。OAS1和OAS3的高mRNA表达与所有乳腺癌患者的不良预后相关，而OAS2与良好的预后相关。还描述了OAS家族在不同临床病理亚型中的预后价值。在DNA甲基化水平上，OAS2中的cg12560128，OASL中的cg06800840和cg26328872显示出显着的预后价值。高/低风险无总生存组中OAS成员签名的mRNA表达与高/低风险无复发生存组相反。在肿瘤免疫浸润评估中，中性粒细胞与所有OAS成员的相关性最高。这项研究提供了对OAS在乳腺癌中具有潜在机制价值的预后作用的新见解。