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Co(III)-Catalyzed C-H Amidation of Nitrogen-Containing Heterocycles with Dioxazolones under Mild Conditions.
The Journal of Organic Chemistry ( IF 3.6 ) Pub Date : 2020-06-19 , DOI: 10.1021/acs.joc.0c01237 Ankit Kumar Dhiman 1 , Ankita Thakur 1 , Inder Kumar 1 , Rakesh Kumar 1 , Upendra Sharma 1
The Journal of Organic Chemistry ( IF 3.6 ) Pub Date : 2020-06-19 , DOI: 10.1021/acs.joc.0c01237 Ankit Kumar Dhiman 1 , Ankita Thakur 1 , Inder Kumar 1 , Rakesh Kumar 1 , Upendra Sharma 1
Affiliation
A cobalt(III)-catalyzed C-8 selective C–H amidation of quinoline N-oxide using dioxazolone as an amidating reagent under mild conditions is disclosed. The reaction proceeds efficiently with excellent functional group compatibility. The utility of the current method is demonstrated by gram scale synthesis of C-8 amide quinoline N-oxide and by converting this amidated product into functionalized quinolines. Furthermore, the developed catalytic method is also applicable for C-7 amidation of N-pyrimidylindolines and ortho-amidation of benzamides.
中文翻译:
轻度条件下Co(III)催化的含氮杂环与二恶唑酮的CH酰胺化
公开了在温和条件下使用重氮唑啉作为酰胺化试剂的钴(III)催化的喹啉N-氧化物的C-8选择性C–H酰胺化。该反应以优异的官能团相容性有效地进行。通过克规模合成C-8酰胺喹啉N-氧化物并将该酰胺化产物转化为官能化喹啉,证明了本方法的实用性。此外,开发的催化方法也适用于N-嘧啶二氢吲哚的C-7酰胺化和苯甲酰胺的正酰胺化。
更新日期:2020-07-17
中文翻译:
轻度条件下Co(III)催化的含氮杂环与二恶唑酮的CH酰胺化
公开了在温和条件下使用重氮唑啉作为酰胺化试剂的钴(III)催化的喹啉N-氧化物的C-8选择性C–H酰胺化。该反应以优异的官能团相容性有效地进行。通过克规模合成C-8酰胺喹啉N-氧化物并将该酰胺化产物转化为官能化喹啉,证明了本方法的实用性。此外,开发的催化方法也适用于N-嘧啶二氢吲哚的C-7酰胺化和苯甲酰胺的正酰胺化。