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Association study of common functional genetic polymorphisms in SLC6A4 (5-HTT) and MAOA genes with obesity in portuguese children
Archives of Physiology and Biochemistry ( IF 3 ) Pub Date : 2020-06-18 , DOI: 10.1080/13813455.2020.1779312
Licínio Manco 1 , Aristides M Machado-Rodrigues 1, 2 , Cristina Padez 1
Affiliation  

Abstract

Objectives

To investigate the association of polymorphisms in SLC6A4 and MAOA genes with obesity indices in children.

Material and Methods

A total of 637 Portuguese children (317 girls; 320 boys) aged 3–11 years-old were genotyped for the SLC6A4 polymorphisms, 5-HTTLPR and STin2, and for a MAOA VNTR. Polymorphisms were analysed by PCR-based methods.

Results

Although non-significant (p = .089), our study revealed the Stin2 10 minor allele with a marked higher frequency in girls with overweight/obesity (0.466) in comparison with controls (0.376). Combining the two SLC6A4 polymorphisms, haplotype S/12 revealed in girls significant or nominally significant protective effects against BMI (β = −0.615; p = .009), BMI Z-score (β = −0.251; p = .006), WC (β = −1.4; p = .02) and WHtR (β = −0.008; p = .04).

Conclusions

We found some evidences for the role of SLC6A4 gene in measures of childhood obesity, mainly in girls.



中文翻译:

SLC6A4(5-HTT)和MAOA基因常见功能遗传多态性与葡萄牙儿童肥胖的关联研究

摘要

目标

探讨SLC6A4MAOA基因多态性与儿童肥胖指数的关系。

材料与方法

总共对 637 名 3-11 岁的葡萄牙儿童(317 名女孩;320 名男孩)进行了SLC6A4多态性、5-HTTLPR 和 STin2 以及MAOA VNTR 的基因分型。通过基于PCR的方法分析多态性。

结果

虽然不显着 ( p  = .089),但我们的研究显示,与对照组 (0.376) 相比,超重/肥胖女孩 (0.466) 的 Stin2 10 次要等位基因频率明显更高。结合两种SLC6A4多态性,单倍型 S/12 在女孩中显示出显着或名义上显着的 BMI 保护作用(β = -0.615;p  = .009)、BMI Z 评分(β = -0.251; p = .006  )、WC (β = -1.4; p  = .02) 和 WHtR (β = -0.008; p  = .04)。

结论

我们发现了一些证据表明SLC6A4基因在儿童肥胖测量中的作用,主要是在女孩中。

更新日期:2020-06-18
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