2.0 MeV proton beam accelerated at Tandetron is extracted in air through a thin film and allowed to scatter to irradiate the cell culture attached to the polymeric base of a biological flask. The irradiated cells were human medulloblastoma cell line Daoy treated with and without 5 nm sized spherical gold nanoparticles. Proton doses from 0.5 to 1.5 Gy have been employed to irradiate the cultures and to investigate the role of the radiotherapy performed with and without the use of the gold nanoparticles. Results indicated that cell survival is significantly reduced to about 50% when the nanoparticles at a concentration of about 6 × 1013 particles/ml are employed.

中文翻译：

---

在 CANAM 实验室对成神经管细胞瘤细胞系 DAOY 进行质子治疗的物理研究

在 Tandetron 加速的 2.0 MeV 质子束通过薄膜在空气中提取，并使其散射以照射附着在生物烧瓶聚合物底座上的细胞培养物。照射的细胞是用和不用5nm大小的球形金纳米颗粒处理的人髓母细胞瘤细胞系Daoy。已采用 0.5 至 1.5 Gy 的质子剂量对培养物进行照射，并研究使用和不使用金纳米粒子进行的放射治疗的作用。结果表明，当采用浓度约为 6 × 1013 颗粒/毫升的纳米颗粒时，细胞存活率显着降低至约 50%。