The difference between the female and male immune response to COVID-19 infection, and infections in general, is multifactorial. The well-known determiners of the immune response, such as X and Y chromosomes, sex hormones, and microbiota, are functionally interconnected and influence each other in shaping the organism’s immunity. We focus our commentary on the interplay between the genetic sex and mitochondria and how this may affect a sex-dependent immune response in COVID-19 infection. Realizing the existence of these interactions may help in designing novel methods or fine-tuning the existing and routine therapies to fight COVID-19 and other infections.
Int Arch Allergy Immunol

中文翻译：

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遗传性别和线粒体在应对 COVID-19 感染中的作用。

女性和男性对 COVID-19 感染以及一般感染的免疫反应之间的差异是多因素的。X 和 Y 染色体、性激素和微生物群等众所周知的免疫反应决定因素在功能上相互关联，并在塑造生物体免疫力方面相互影响。我们的评论重点是遗传性别和线粒体之间的相互作用，以及这如何影响 COVID-19 感染中的性别依赖性免疫反应。认识到这些相互作用的存在可能有助于设计新方法或微调现有和常规疗法来对抗 COVID-19 和其他感染。
Int Arch 过敏免疫