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Esc-1GN shows therapeutic potentials for acne vulgaris and inflammatory pain.
Journal of Peptide Science ( IF 2.1 ) Pub Date : 2020-06-18 , DOI: 10.1002/psc.3269
Tiaofei Ye 1, 2 , Jiena Wu 2 , Zhengnan Xu 3 , Jinwei Chai 2 , Qingye Zeng 2 , Baishuang Zeng 2 , Yahua Gao 2 , Ruiyin Guo 2 , Xin Chen 1 , Xueqing Xu 2
Affiliation  

The inflammatory response plays important roles in acne vulgaris and pain pathogenesis. In previous study, Esc‐1GN with anti‐inflammatory, antimicrobial, and lipopolysacchride (LPS) binding activity was identified from the skin of the frog Hylarana guentheri. Here, we report its therapeutic potentials for acne vulgaris and inflammatory pain. Esc‐1GN destroyed the cell membrane of Propionibacteria acnes in the membrane permeability assays. In addition, bacterial agglutination test suggested that Esc‐1GN triggered the agglutination of P. acnes, which was affected by LPS and Ca2+. Meanwhile, in vivo anti‐P. acnes and anti‐inflammatory effects of Esc‐1GN were confirmed by reducing the counts of P. acnes in mice ear, relieving P. acnes‐induced mice ear swelling, decreasing mRNA expression and the production of pro‐inflammatory cytokines, and attenuating the infiltration of inflammatory cells. Moreover, Esc‐1GN also displayed antinociceptive effect in mice induced by acetic acid and formalin. Therefore, Esc‐1GN is a promising candidate drug for treatment of acne vulgaris and inflammatory pain.

中文翻译:

Esc-1GN显示出寻常痤疮和炎性疼痛的治疗潜力。

炎症反应在寻常痤疮和疼痛发病机理中起重要作用。在先前的研究中,从青蛙Hylarana guentheri的皮肤中鉴定出具有抗炎,抗微生物和脂多糖(LPS)结合活性的Esc-1GN 。在这里,我们报告其治疗寻常痤疮和炎性疼痛的潜力。Esc-1GN在膜通透性测定中破坏了痤疮丙酸杆菌的细胞膜。此外,细菌凝集试验表明,Esc-1GN触发了痤疮丙酸杆菌的凝集,这受到LPS和Ca 2+的影响。同时,通过减少Esc-1GN的数量证实了Esc-1GN的体内抗痤疮丙酸杆菌和抗炎作用。小鼠耳中的痤疮丙酸杆菌,缓解痤疮丙酸杆菌诱导的小鼠耳肿胀,降低mRNA表达和促炎细胞因子的产生,并减弱炎症细胞的浸润。此外,Esc-1GN还对乙酸和福尔马林诱导的小鼠具有镇痛作用。因此,Esc-1GN是治疗寻常痤疮和炎性疼痛的有前途的候选药物。
更新日期:2020-06-18
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