A novel copper-catalyzed sp³-carbon radical/carbamoyl radical cross-coupling protocol for the construction of C(sp³)-C(O) bond is described. This provides a straightforward method for synthesis of 2-carbamoyl-1,3-dicarbonyl compounds in good to excellent yields under mild conditions. Mechanistic studies confirms the generation of both carbamoyl and C(sp³)-centered radicals directly from oxidation of C(sp³)-H bond of formamides and 1,3-dicarbonyl compounds, respectively.

中文翻译：

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铜催化的sp ^3-碳自由基/氨基甲酰基自由基交叉偶联：1,3-二羰基化合物的氨基甲酰基化的直接策略

描述了一种新型的铜催化的sp ^3-碳自由基/氨基甲酰基自由基交叉偶联方案，用于构建C（sp ³）-C（O）键。这提供了一种在温和条件下以高至优异的产率合成2-氨基甲酰基-1,3-二羰基化合物的简单方法。机理研究证实，分别由甲酰胺和1,3-二羰基化合物的C（sp ³）-H键氧化直接生成氨基甲酰基和以C（sp ³）为中心的自由基。