Emerging evidence indicates that intranasal delivery of neuropeptide Y (NPY) to the brain has therapeutic potential for management of stress-triggered neuropsychiatric disorders. Here we aimed to determine how intranasal administration of NPY, either before or immediately after, traumatic stress in single prolonged stress (SPS) rodent model of Post-traumatic stress disorder (PTSD) impacts food consumption and body weight. SPS stressors suppressed food consumption for at least two days in the vehicle-treated animals. When given prior to SPS stressors, intranasal NPY prevented the SPS-elicited reduction in food intake only for several hours afterwards. When given after the SPS stressors, under conditions shown to prevent behavioral and biochemical impairments, intranasal NPY had no effect on food intake. Although all groups showed circadian variation, the SPS-exposed rats ate less than unstressed animals during the dark (active) phase. Seven days after exposure to SPS stressors, there were no differences in food intake, although body weight was still lower than unstressed controls in all the experimental groups. Thus, traumatic stress has pronounced effect on food consumption during the rodent's active phase, and a prolonged effect on body weight. Single intranasal infusion of NPY, which was previously shown to prevent development of several PTSD associated behavioral and neuroendocrine impairments, did not elicit prolonged changes in stress triggered food consumption nor regulation of body weight.

中文翻译：

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神经肽Y鼻内给药和单一长时间应激对雄性大鼠摄食量和体重的影响

新出现的证据表明，将神经肽 Y (NPY) 鼻内递送至大脑具有治疗压力引发的神经精神疾病的潜力。在这里，我们旨在确定在创伤后应激障碍 (PTSD) 的单一长期应激 (SPS) 啮齿动物模型中的创伤应激之前或之后鼻内给药 NPY 如何影响食物消耗和体重。SPS 应激物在载体处理的动物中抑制食物消耗至少两天。当在 SPS 压力源之前给予时，鼻内 NPY 仅在之后的几个小时内阻止了 SPS 引起的食物摄入减少。在 SPS 压力源之后给予时，在显示可防止行为和生化障碍的条件下，鼻内 NPY 对食物摄入量没有影响。尽管所有组都表现出昼夜节律变化，但在黑暗（活跃）阶段，暴露于 SPS 的大鼠比未受应激的动物吃得少。暴露于 SPS 压力源 7 天后，食物摄入量没有差异，尽管所有实验组的体重仍低于未受压力的对照组。因此，创伤应激对啮齿动物活跃期的食物消耗有显着影响，并对体重有长期影响。NPY 的单次鼻内输注，以前被证明可以防止几种与 PTSD 相关的行为和神经内分泌障碍的发展，但不会引起压力引发的食物消耗或体重调节的长期变化。尽管所有实验组的体重仍低于未受压力的对照组，但食物摄入量没有差异。因此，创伤应激对啮齿动物活跃期的食物消耗有显着影响，并对体重有长期影响。NPY 的单次鼻内输注，以前被证明可以防止几种与 PTSD 相关的行为和神经内分泌障碍的发展，但不会引起压力引发的食物消耗或体重调节的长期变化。尽管所有实验组的体重仍低于未受压力的对照组，但食物摄入量没有差异。因此，创伤应激对啮齿动物活跃期的食物消耗有显着影响，对体重有长期影响。NPY 的单次鼻内输注，以前被证明可以防止几种与 PTSD 相关的行为和神经内分泌障碍的发展，但不会引起压力引发的食物消耗或体重调节的长期变化。