The ubiquitin proteasome pathway is conserved from yeast to mammals and is necessary for the targeted degradation of most short-lived proteins in eukaryotic cells. Its protein substrates include cell cycle regulatory proteins and proteins that are not properly folded in the endoplasmic reticulum. Owing to the ubiquity of its protein substrates, ubiquitination regulates a variety of cellular activities, including cell proliferation, apoptosis, autophagy, endocytosis, DNA damage repair, and immune response. With new genomic data continuously being obtained, ubiquitination through genomic data analysis will be an effective method. We obtained 83 overlapping genes from four glioma databases, which differed from ubiquitin ligase Nrdp1 expression, including 36 downregulated and 47 upregulated genes. The KEGG pathways, molecular functions, cellular components, and biological processes potentially associated with Nrdp1 were obtained using GSEA and Cytoscape. In human gliomas, differences in the expression of Nrdp1 were identified between nontumor brain tissue and different glioma tissues, but no difference in expression was found between low‑grade glioma (LGG) and anaplastic glioma (AG). In survival analysis, we found no significant association between Nrdp1 expression level and patient prognosis.

中文翻译：

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神经胶质瘤数据库中泛素连接酶 Nrdp1 相关蛋白的预测。

泛素蛋白酶体途径从酵母到哺乳动物都是保守的，并且对于真核细胞中大多数短寿命蛋白质的靶向降解是必需的。其蛋白质底物包括细胞周期调节蛋白和在内质网中未正确折叠的蛋白质。由于其蛋白质底物的普遍存在，泛素化调节多种细胞活动，包括细胞增殖、细胞凋亡、自噬、内吞作用、DNA 损伤修复和免疫反应。随着不断获得新的基因组数据，通过基因组数据分析泛素化将是一种有效的方法。我们从四个神经胶质瘤数据库中获得了 83 个与泛素连接酶 Nrdp1 表达不同的重叠基因，包括 36 个下调基因和 47 个上调基因。KEGG通路，分子功能，使用 GSEA 和 Cytoscape 获得了可能与 Nrdp1 相关的细胞成分和生物过程。在人类神经胶质瘤中，在非肿瘤脑组织和不同神经胶质瘤组织之间发现了 Nrdp1 表达的差异，但在低级别神经胶质瘤 (LGG) 和间变性神经胶质瘤 (AG) 之间未发现表达差异。在生存分析中，我们发现 Nrdp1 表达水平与患者预后之间没有显着关联。