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Analysis of HLA-G protein expression in leprosy.
Immunogenetics ( IF 3.2 ) Pub Date : 2020-06-19 , DOI: 10.1007/s00251-020-01168-4
Camila Rodrigues da Silva 1 , Lucas Henrique Ferreira Sampaio 2 , Maurício Barcelos Costa 1 , Maria Auxiliadora de Paula Carneiro Cysneiros 1 , Ibrahim Abiodoun Sadissou 3 , Mirian Lane de Oliveira Rodrigues Castilho 1 , Jonathan Ballico de Moraes 2 , Eduardo Antonio Donadi 3 , Isabela Jubé Wastoswki 2, 4
Affiliation  

The aim of this study was to evaluate the expression of human leukocyte antigen G (HLA-G) in leprosy. Biopsy and serum samples were collected from 18 patients presenting with leprosy and from healthy controls. Samples were analyzed using immunohistochemistry and ELISA techniques. HLA-G expression was observed in biopsy samples of all patients. The healthy control samples were consistently negative for HLA-G expression. Control plasma samples displayed significantly higher HLA-G expression than those from the patients (p < 0.01). These results are the first demonstration of the expression of HLA-G in leprosy.



中文翻译:

麻风中HLA-G蛋白表达的分析。

这项研究的目的是评估麻风病中人类白细胞抗原G(HLA-G)的表达。从18例麻风病患者和健康对照中收集活检和血清样本。使用免疫组织化学和ELISA技术分析样品。在所有患者的活检样本中均观察到HLA-G表达。健康对照样品的HLA-G表达始终阴性。对照血浆样品显示的HLA-G表达明显高于患者血浆中的HLA-G表达(p  <0.01)。这些结果是HLA-G在麻风病中表达的首次证明。

更新日期:2020-06-19
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