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Anosmia in COVID-19: Mechanisms and Significance.
Chemical Senses ( IF 3.5 ) Pub Date : 2020-06-17 , DOI: 10.1093/chemse/bjaa040
Albert Y Han 1 , Laith Mukdad 1 , Jennifer L Long 1, 2 , Ivan A Lopez 1
Affiliation  

The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a challenge for prevention due to asymptomatic or paucisymptomatic patients. Anecdotal and preliminary evidence from multiple institutions shows that these patients present with a sudden onset of anosmia without rhinitis. We aim to review the pathophysiology of anosmia related to viral upper respiratory infections and the prognostic implications. Current evidence suggests that SARS-CoV-2-related anosmia may be a new viral syndrome specific to COVID-19 and can be mediated by intranasal inoculation of SARS-CoV-2 into the olfactory neural circuitry. The clinical course of neuroinvasion of SARS-CoV-2 is yet unclear; however, an extended follow-up of these patients to assess for neurological sequelae, including encephalitis, cerebrovascular accidents, and long-term neurodegenerative risk may be indicated.

中文翻译:

COVID-19中的失眠症:机制和意义。

严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)引起的全球冠状病毒疾病2019(COVID-19)大流行仍然是无症状或多症状患者的预防挑战。来自多个机构的轶事和初步证据表明,这些患者突然出现了无鼻炎的失眠症。我们的目的是审查与病毒性上呼吸道感染有关的失眠的病理生理学及其预后意义。目前的证据表明,SARS-CoV-2相关的失眠症可能是针对COVID-19的新型病毒综合征,可以通过鼻内接种SARS-CoV-2进入嗅觉神经回路来介导。SARS-CoV-2神经侵袭的临床过程尚不清楚。但是,对这些患者进行了广泛的随访以评估神经系统后遗症,
更新日期:2020-07-07
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