当前位置: X-MOL 学术Transl. Psychiaty › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The efficacy and safety of omega-3 fatty acids on depressive symptoms in perinatal women: a meta-analysis of randomized placebo-controlled trials.
Translational Psychiatry ( IF 6.8 ) Pub Date : 2020-06-17 , DOI: 10.1038/s41398-020-00886-3
Mi-Mi Zhang 1, 2 , Yan Zou 3 , Su-Min Li 4 , Li Wang 4 , Yu-Hui Sun 5 , Le Shi 6 , Lin Lu 1, 6 , Yan-Ping Bao 1 , Su-Xia Li 1
Affiliation  

Omega-3 fatty acids (FA), as a nutrient, has been proven effective in major depressive disorder (MDD), however, the results of monotherapy in perinatal depression (PND) remain unclear. To examine the efficacy and safety of omega-3 fatty acids (FA) monotherapy for perinatal depression (PND) compared with placebo. PubMed, Embase, PsycINFO, MEDLINE, Cochrane Library, and CINAHL were searched from inception up to November 2019. The reference lists of relevant review articles and included studies were also reviewed. Randomized placebo-controlled trials examining the efficacy and safety of omega-3 FA monotherapy in perinatal women with depressive symptoms were included. Pooled standard mean differences (SMD) were calculated and random-effects models were adopted for all analyses. Subgroups analyses and meta-regression were performed to quantify characteristics of the subjects and trials influencing the omega-3 response. In addition, meta-regression was conducted to identify the source of heterogeneity. The study protocol was registered at PROSPERO, CRD42020159542. Eight eligible randomized placebo-controlled trials were included involving 638 participants. There was a significant effect of omega-3 FA on perinatal depression. Omega-3 with higher ratio of EPA/DHA (≥1.5) had significant efficacy both in mild-to-moderate pregnant and postpartum depression with low incidence of side effects. Among the included trials reporting adverse effects, there was no significant difference in incidence of gastrointestinal and neurologic events between the omega-3 and placebo groups. There was no evidence of publication bias. Our findings suggested that omega-3 FA significantly improved depressive symptoms in perinatal women regardless of pregnant or postpartum and well-tolerated. Furthermore, the omega-3 response was linked to higher EPA proportion in omega-3 formula and mild- to-moderate depression.



中文翻译:

omega-3 脂肪酸对围产期妇女抑郁症状的功效和安全性:随机安慰剂对照试验的荟萃分析。

Omega-3 脂肪酸 (FA) 作为一种营养素,已被证明对重度抑郁症 (MDD) 有效,但单药治疗围产期抑郁症 (PND) 的结果仍不清楚。旨在检查 omega-3 脂肪酸 (FA) 单一疗法与安慰剂相比对围产期抑郁症 (PND) 的疗效和安全性。PubMed、Embase、PsycINFO、MEDLINE、Cochrane Library 和 CINAHL 的检索时间从建库到 2019 年 11 月。还对相关综述文章和纳入研究的参考文献列表进行了综述。其中包括随机安慰剂对照试验,检验 omega-3 FA 单一疗法对患有抑郁症状的围产期妇女的疗效和安全性。计算汇总标准均差(SMD),并采用随机效应模型进行所有分析。进行亚组分析和荟萃回归以量化影响 omega-3 反应的受试者特征和试验。此外,还进行了荟萃回归来确定异质性的来源。该研究方案已在 PROSPERO 注册,CRD42020159542。纳入了 8 项符合条件的随机安慰剂对照试验,涉及 638 名参与者。omega-3 FA 对围产期抑郁症有显着影响。EPA/DHA比例较高(≥1.5)的Omega-3对轻中度孕产后抑郁症疗效显着,且副作用发生率低。在报告不良反应的纳入试验中,omega-3 组和安慰剂组之间胃肠道和神经系统事件的发生率没有显着差异。没有证据表明存在发表偏倚。我们的研究结果表明,omega-3 FA 可以显着改善围产期妇女的抑郁症状,无论是怀孕还是产后,并且耐受性良好。此外,omega-3 反应与 omega-3 配方奶粉中较高的 EPA 比例和轻度至中度抑郁症有关。

更新日期:2020-06-18
down
wechat
bug