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Relationship between the Monocyte Chemo-attractant Protein-1 gene rs1024611 A>G Polymorphism and Cancer Susceptibility: A Meta-analysis Involving 14,617 Subjects
Immunological Investigations ( IF 2.8 ) Pub Date : 2020-06-18 , DOI: 10.1080/08820139.2020.1776726
Zhan Chen 1 , Shiping Yin 2 , Liang Zheng 3 , Weifeng Tang 4 , Mingqiang Kang 4, 5, 6 , Wei Wei 1 , Kang Sui 1
Affiliation  

ABSTRACT

Background

Inflammatory and inducible chemokines are the hallmarks of malignancy. Monocyte chemo-attractant protein-1 (MCP-1) is a crucial chemokine implicated in infection and inflammation. Methods: We performed an updated meta-analysis of thirty independent case-control studies with 6,777 cancer cases and 7,840 controls to determine if the MCP-1 gene rs1024611 A > G variant is associated with the risk of cancer. Results: The G allele carriers of rs1024611 in the MCP-1 gene might have a null association with cancer risk in overall comparison. In a subgroup analysis by ethnicity, we identified a marked association between the MCP-1 G allele rs1024611 polymorphism and cancer risk in the Caucasian populations (GG vs. AA: OR = 1.72, 95% CI, 1.12–2.64, P = .013, and GG vs. AG/AA: OR = 1.82, 95% CI, 1.19–2.78, P = .006). The potential bias in literature selection was witnessed in this meta-analysis (G vs. A: PBegg’s = 0.187, PEgger’s = 0.049; and GG/GA vs. AA: PBegg’s = 0.069, PEgger’s = 0.024). The adjusted ORs and CIs of the nonparametric “trim-and-fill” method demonstrated the reliability of these findings. The outcome of heterogeneity analysis indicated that heterogeneity might be due to small sample sizes (<1000 subjects), cancer types (bladder cancer, other cancers), ethnicity (Asians), and population-based studies. However, the sensitivity analysis validated the reliability of the findings. Conclusion: In conclusion, this updated meta-analysis showed that the G carrier of the MCP-1 gene rs1024611 is associated with susceptibility to cancer in Caucasian.



中文翻译:

单核细胞趋化蛋白1基因rs1024611 A>G多态性与癌症易感性的关系:一项涉及14,617名受试者的Meta分析

摘要

背景

炎症和诱导趋化因子是恶性肿瘤的标志。单核细胞趋化蛋白-1 (MCP-1) 是一种与感染和炎症有关的关键趋化因子。方法:我们对 6,777 名癌症病例和 7,840 名对照的 30 项独立病例对照研究进行了更新的荟萃分析,以确定MCP-1基因 rs1024611 A > G 变异是否与癌症风险相关。结果:在总体比较中,MCP-1基因中 rs1024611 的 G 等位基因携带者可能与癌症风险无关联。在按种族进行的亚组分析中,我们确定了MCP-1  G 等位基因 rs1024611 多态性与高加索人群 (GG. AA:OR = 1.72,95% CI,1.12–2.64,P = .013,GG vs . AG/AA:OR = 1.82,95% CI,1.19–2.78,P = .006 )。在这项荟萃分析中见证了文献选择的潜在偏差(G vs . A:P Begg's  = 0.187,P Egger's  = 0.049;和 GG/GA vs . AA:P Begg's  = 0.069,P Egger's = 0.024)。非参数“修剪和填充”方法的调整后 OR 和 CI 证明了这些发现的可靠性。异质性分析的结果表明,异质性可能是由于样本量小(<1000 名受试者)、癌症类型(膀胱癌、其他癌症)、种族(亚洲人)和基于人群的研究。然而,敏感性分析验证了结果的可靠性。结论:总之,这项更新的荟萃分析表明,MCP-1基因 rs1024611的 G 携带者与白种人的癌症易感性有关。

更新日期:2020-06-18
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