All eight stereoisomers of conidendrin were synthesized from (1 R,2 S,3 S)-1-(4-benzyloxy-3-methoxyphenyl)-3-(4-benzyloxy-3-methoxybenzyl)-2- hydroxymethyl-1,4-butanediol ((+)-4) and its enantiomer with high optical purity. The configurations at 4-positions of the conidendrin stereoisomers were constructed by intramolecular Friedel-Crafts reaction of protected 4. After conversion to tetrahydronaphthalene intermediate 7a, the 2- and 3-position of tetrahydronaphthalene structure 7a were converted to 3a- and 9a-position of (+)-α-conidendrin (3a), respectively. By the epimerization process of 2- or 3-position of 7a, the other diastereomers were obtained. All enantiomers were also synthesized from (−)-4.

从（1 R，2  S，3  S）-1-（4-苄氧基-3-甲氧基苯基）-3-（4-苄氧基-3-甲氧基苄基）-2-羟甲基-1,4合成分生孢子蛋白的所有八个立体异构体 -具有高光学纯度的-丁二醇（（+）- 4）及其对映异构体。通过被保护的4的分子内Friedel-Crafts反应，构建了分生孢子蛋白立体异构体4位的构型。转化为四氢萘中间体7a后，将四氢萘结构7a的2-位和3-位分别转化为（+）-α-分枝烯苷（3a）的3a位和9a位。通过2a或3位7a的差向异构过程，获得了其他非对映异构体。所有对映体也由（-）- 4合成。