Recent studies have demonstrated that chemerin participates in the regulation of female reproductive function at the level of the ovaries. Due to the lack of data concerning the presence of the chemerin system (chemerin and its receptors: CMKLR1, GPR1, CCRL2) in the ovaries of pigs, one of the most economically important livestock species, the aim of this study was to investigate the expression and localization of chemerin and its receptors in the ovaries of prepubertal and mature gilts. We also aimed to examine the concentrations of chemerin in the follicular fluid of prepubertal and mature animals. In the present study, we have demonstrated the expression patterns of chemerin system components in the porcine follicles of different sizes of prepubertal and mature animals, as well as in corpora lutea of mature gilts during the estrous cycle and early pregnancy. The obtained results suggest that the expression of chemerin system components is influenced by the reproductive stage, cell type, and the hormonal status of gilts (the estrous cycle/pregnancy). We have also presented the localization of the chemerin system components in various ovarian structures, and also showed changes in the concentration of chemerin in the follicular fluid of pigs. The presented findings not only confirm that chemerin is produced locally in the porcine ovary but they also demonstrate that chemerin directly affects ovarian cells, as confirmed by the presence of chemerin receptors in all ovarian structures. Therefore, chemerin appears to be an important intra‐ovarian factor that could regulate ovary function in pigs.

中文翻译：

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凯莫瑞及其受体在青春期前和成熟后备母猪卵巢中的表达。

最近的研究表明，凯莫瑞在卵巢水平参与女性生殖功能的调节。由于缺乏有关猪（经济上最重要的牲畜物种之一）卵巢中凯莫瑞系统（凯莫瑞及其受体：CMKLR1、GPR1、CCRL2）存在的数据，本研究的目的是调查猪卵巢中凯莫瑞系统（凯莫瑞及其受体：CMKLR1、GPR1、CCRL2）的表达情况。以及凯莫瑞及其受体在青春期前和成熟后备母猪卵巢中的定位。我们还旨在检查青春期前和成熟动物卵泡液中凯莫瑞的浓度。在本研究中，我们展示了凯莫瑞系统成分在青春期前和成熟动物不同大小的猪卵泡中以及发情周期和妊娠早期成熟后备母猪黄体中的表达模式。获得的结果表明，凯莫瑞系统成分的表达受到后备母猪的繁殖阶段、细胞类型和激素状态（动情周期/妊娠）的影响。我们还介绍了凯莫瑞系统成分在各种卵巢结构中的定位，并显示了猪卵泡液中凯莫瑞浓度的变化。所提出的研究结果不仅证实了凯莫瑞是在猪卵巢中局部产生的，而且还证明了凯莫瑞直接影响卵巢细胞，正如所有卵巢结构中存在凯莫瑞受体所证实的那样。因此，凯莫瑞似乎是调节猪卵巢功能的重要卵巢内因子。