Linear energy transfer (LET)‐guided methods have been applied to intensity‐modulated proton therapy (IMPT) to improve its biological effect. However, using LET as a surrogate for biological effect ignores the topological relationship of the scanning spot to different structures of interest. In this study, we developed an optimization method that takes advantage of the continuing increase in LET beyond the physical dose Bragg peak. This method avoids placing high biological effect values in critical structures and increases biological effect in the tumor area without compromising target coverage.

中文翻译：

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一种生物效应指导的优化方法，使用束远侧回避技术进行强度调节质子治疗。

线性能量转移（LET）指导的方法已应用于强度调节质子治疗（IMPT），以改善其生物学效应。但是，使用LET作为生物效应的替代品会忽略扫描点与感兴趣的不同结构的拓扑关系。在这项研究中，我们开发了一种优化方法，该方法利用了LET超过物理剂量Bragg峰的持续增加的优势。该方法避免在关键结构中放置高生物学效应值，并在不损害靶标覆盖范围的情况下增加了肿瘤区域的生物学效应。