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Zinc Oxide Nanoparticles Supported on Multi‐walled Carbon Nanotube Modified Electrode for Electrochemical Sensing of a Fluoroquinolone Drug
Electroanalysis ( IF 3 ) Pub Date : 2020-06-18 , DOI: 10.1002/elan.202000010
K. S. Siddegowda 1 , B. Mahesh 1 , N. A. Chamaraja 1 , B. Roopashree 1 , N. Kumara Swamy 2 , G. S. Nanjundaswamy 3
Affiliation  

A facile, and novel construction strategy invented on electrochemical procedures for the assemblage of zinc oxide nanoparticles (ZnO NPs) with a multiwalled carbon nanotube modified carbon paste electrode (ZnO‐MWCNTMCPE) to ascertain the fluoroquinolone drug‐Moxifloxacin (MOX). The ZnO‐MWCNTMCPE can significantly improve the electron transfer process and lessen the impedance of the surface of the electrode. Besides, the oxidation of MOX has remarkably enhanced on the modified electrode. Under the optimal experimental conditions, the empirical results exhibited that the oxidation peak current was linearly proportional to the concentration of MOX in the range of 1.0×10−7 to 2.4×10−6 mol L−1 with a detection limit of 0.452×10−7 mol L−1. To analyze the practicality of the MOX determination technique in real samples, the intended sensor manipulated for the adjudication of MOX in human urine specimens, and the results authenticated the explore of MOX with the highest accuracy. Further, the proposed sensor system exercised for the simultaneous evaluation of paracetamol (ACOP) and MOX, the DPV technique unveiled the well‐separated peaks among ACOP (0.188 mV) and MOX (0.814 mV) with a peak separation (ΔE) of 626 mV in real samples. Therefore, the suggested system could sense and discover the MOX in the biological systems.

中文翻译:

多壁碳纳米管修饰电极上负载的氧化锌纳米粒子对氟喹诺酮类药物的电化学感应

电化学方法发明了一种简便而新颖的构建策略,用于将氧化锌纳米颗粒(ZnO NPs)与多壁碳纳米管修饰的碳糊电极(ZnO-MWCNTMCPE)组装,以确定氟喹诺酮类药物莫西沙星(MOX)。ZnO-MWCNTMCPE可以显着改善电子转移过程并降低电极表面的阻抗。此外,在修饰电极上MOX的氧化显着增强。在最佳实验条件下,实验结果表明,氧化峰电流与MOX的浓度在1.0×10 -7至2.4×10 -6  mol L -1范围内呈线性比例关系,检出限为0.452×10 -7 摩尔升-1。为了分析MOX测定技术在实际样品中的实用性,操纵了预期的传感器来判断人尿标本中的MOX,结果验证了MOX的最高准确性。此外,为同时评估对乙酰氨基酚(ACOP)和MOX而使用的拟议传感器系统,DPV技术揭示了ACOP(0.188 mV)和MOX(0.814 mV)之间分离良好的峰,峰分离(ΔE)为626 mV在真实样本中。因此,建议的系统可以感知并发现生物系统中的MOX。
更新日期:2020-06-18
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