Recent evidence has associated mood disorders with blood‐brain barrier (BBB)/ neurovascular unit (NVU) dysfunction, and reduction in blood vessels coverage by the water channel aquaporin‐4 (AQP4) immunoreactive astrocytes. Lithium is an established treatment for mood disorders, yet, its mechanism of action is partially understood. We investigated the effects of lithium on BBB integrity and NVU‐related protein expression in chronic mild stress (CMS) rat model of depressive‐like behavior.

中文翻译：

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锂对抑郁样行为模型大鼠海马血脑屏障完整性的调节作用

最近的证据表明情绪障碍与血脑屏障（BBB）/神经血管单位（NVU）功能障碍以及水通道aquaporin-4（AQP4）免疫反应性星形胶质细胞的血管覆盖减少有关。锂是一种用于情绪障碍的公认治疗方法，但是，其作用机理已被部分理解。我们研究了锂对抑郁样行为的慢性轻度应激（CMS）大鼠模型中BBB完整性和NVU相关蛋白表达的影响。