The physical cues in the extracellular environment play important roles in cancer cell metastasis. However, how metastatic cancer cells respond to the diverse mechanical environments of metastatic sites is not fully understood. Here, substrates with different mechanical properties are prepared to simulate the extracellular mechanical environment of various human tissues. The prostate cancer (PC) cells derived from different cancer metastasis sites show heterogeneity in mechanical response. This heterogeneity mediates two distinct metastasis patterns. High stiffness promotes individual cell migration and proliferation by inducing Yes‐associated protein and tafazzin (YAP/TAZ) nuclear localization in bone metastasis‐derived cells, whereas low stiffness promotes cell migration and proliferation by inducing lymphatic metastasis‐derived cells to form clusters characterized by high expression of CD44. The different metastasis patterns induced by the mechanical properties of the extracellular environment are crucial in the development of PC.

中文翻译：

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前列腺癌细胞诱导不同转移模式对机械力的异质反应。

细胞外环境中的物理提示在癌细胞转移中起重要作用。然而，尚未完全了解转移癌细胞如何对转移部位的多种机械环境作出反应。在这里，准备了具有不同机械性能的基材来模拟各种人体组织的细胞外机械环境。源自不同癌症转移部位的前列腺癌细胞（PC）在机械反应中表现出异质性。这种异质性介导了两种不同的转移模式。高刚度可通过诱导与骨转移有关的细胞中的Yes相关蛋白和tafazzin（YAP / TAZ）核定位来促进单个细胞的迁移和增殖，低刚度则通过诱导源自淋巴转移的细胞形成以CD44高表达为特征的簇而促进细胞迁移和增殖。由细胞外环境的机械特性引起的不同转移模式对于PC的发展至关重要。