Sprint and endurance training in relation to redox balance, inflammatory status and biomarkers of aging in master athletes.,Nitric Oxide

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Sprint and endurance training in relation to redox balance, inflammatory status and biomarkers of aging in master athletes.
Nitric Oxide ( IF 3.9 ) Pub Date : 2020-06-18 , DOI: 10.1016/j.niox.2020.05.004
Thiago Santos Rosa ₁ , Rodrigo Vanerson Passos Neves ₁ , Lysleine Alves Deus ₁ , Caio Victor Sousa ₁ , Samuel da Silva Aguiar ₁ , Michel Kendy de Souza ₂ , Milton Rocha Moraes ₁ , Érica Carine Campos Caldas Rosa ₃ , Rosangela Vieira Andrade ₄ , Marko T Korhonen ₅ , Herbert Gustavo Simões ₁

Affiliation

Purpose

Studies have shown a positive influence of intense athletic training on several biomarkers of aging, but it remains unclear whether this influence is dependent of exercise-training-mode. This study compared redox balance, cytokine levels and biomarkers of aging between master sprinters and endurance athletes, as well as in young and middle-aged individuals as controls.

Methods

Participants were male master sprinters (SA, 50±8.9yrs; n=13) and endurance runners (EA, 53±8.2yrs; n=18) with remarkable athletic experience (∼25yrs of practice), besides untrained young (YC, 22.7±3.9yrs; n=17) and age-matched controls (MC, 45.5±9.8yrs; n=12). Anamnesis, anthropometrics, biomarkers of aging, inflammation status and oxidative stress parameters were analyzed in all participants.

Results

An increased pro-oxidant activity (elevated protein carbonyl; isoprostanes and 8-OHdG) was observed for MC in comparison to remaining groups (p<0.05). However, SA presented a better antioxidant capacity than both MC and EA, while nitrite/nitrate (NO_x) availability was higher for EA and lower for the MC (p<0.05). Both groups of athletes presented a better anti-inflammatory status than MC (increased IL-10 and lowered IL-6, sIL-6R, sTNF-RI), but worse than YC (increased TNF-α, sTNF-RI, and sIL-6R) (p<0.05). Telomere length was shorter in MC, which also had lower levels of irisin and klotho, and elevated FGF-23 (p<0.05). ADMA levels were higher in MC and SA, while irisin was lower in EA when compared to SA and YC (p<0.05).

Conclusion

Master athletes presented better redox balance and inflammatory status, with decreased biomarkers of aging compared to control. Regarding exercise mode, a better NO- profile, as a marker of endothelial function, was observed for EA, whereas SA had a better redox balance, cytokines profile and attenuated biomarkers of aging.

中文翻译：

有关高手运动员氧化还原平衡，炎症状态和衰老生物标志物的冲刺和耐力训练。

目的

研究表明，剧烈运动训练对衰老的几种生物标志物具有积极影响，但尚不清楚这种影响是否取决于运动训练模式。这项研究比较了短跑大师和耐力运动员之间以及老年人和中年人之间的氧化还原平衡，细胞因子水平和衰老的生物标志物。

方法

参加训练的是男性短跑大师（SA，50±8.9岁; n = 13）和耐力赛跑者（EA，53±8.2yrs; n = 18），他们具有非凡的运动经验（〜25岁练习），此外还有未受训练的年轻人（YC，22.7） ±3.9岁； n = 17）和年龄匹配的对照组（MC，45.5±9.8yrs； n = 12）。回顾了所有参与者的回忆，人体测量学，衰老的生物标记，炎症状态和氧化应激参数。

结果

与其余组相比，MC的促氧化剂活性增加（羰基蛋白，异前列腺素和8-OHdG升高）（p < 0.05）。然而，SA的抗氧化能力优于MC和EA，而EA的亚硝酸盐/硝酸盐（NO _x）利用率较高，MC的亚硝酸盐/硝酸盐（NO _x）利用率较低（p < 0.05）。两组运动员的抗炎状态均优于MC（IL-10升高，IL-6，sIL-6R，sTNF-RI降低），但优于YC（TNF-α，sTNF-RI和sIL-升高）。 6R）（p ＜ 0.05）。MC端粒长度较短，其虹膜素和klotho含量也较低，FGF-23含量较高（p <0.05）。与SA和YC相比，MC和SA中的ADMA水平较高，而EA中的虹膜素较低（p < 0.05）。