Ca²⁺ ions are key second messengers in both excitable and non-excitable cells. Owing to the rather pleiotropic nature of Ca²⁺ transporters and other Ca²⁺-binding proteins, however, Ca²⁺ signaling has attracted limited attention as a potential target of anticancer therapy. Here, we discuss cancer-associated alterations of Ca²⁺ fluxes at specific organelles as we identify novel candidates for the development of drugs that selectively target Ca²⁺ signaling in malignant cells.

中文翻译：

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Ca2 +助焊剂和癌症。

Ca ²⁺离子是可激发和不可激发细胞中的关键第二信使。然而，由于Ca ²⁺转运蛋白和其他Ca ²⁺结合蛋白的多效性，Ca ²⁺信号传导作为抗癌治疗的潜在靶点受到了有限的关注。在这里，我们讨论了在特定细胞器中与癌症相关的Ca ²⁺通量的变化，因为我们确定了开发可选择性靶向恶性细胞中Ca ²⁺信号传导的药物的新型候选物。