Mitochondrial haplogroups F, A, and M7a are associated with increased risks of lifestyle diseases, while haplogroups N9 and D are associated with decreased risks of lifestyle diseases or with longevity. The current study determined the existence of interactions between 5 selected haplogroups and physical activity (PA) on total and high-molecular-weight (HMW) adiponectin in 3,994 men and 6,014 women. The interactions between haplogroups (M7a/D) and PA on adiponectin were significant in men (total and HMW: P-interaction = 0.041 and 0.011). The positive association of PA with adiponectin in men carrying haplogroup M7a is attenuated in comparison to men carrying haplogroup D.

中文翻译：

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日本人群中线粒体单倍群 (M7a/D) 与脂联素体力活动之间的相互作用

线粒体单倍群 F、A 和 M7a 与生活方式疾病风险增加相关，而单倍群 N9 和 D 与生活方式疾病风险降低或长寿相关。目前的研究确定了 3,994 名男性和 6,014 名女性的 5 个选定单倍群与体力活动 (PA) 之间的相互作用对总脂联素和高分子量 (HMW) 脂联素的影响。单倍群 (M7a/D) 和 PA 对脂联素的相互作用在男性中很显着（总和 HMW：P 相互作用 = 0.041 和 0.011）。与携带单倍群 D 的男性相比，携带单倍群 M7a 的男性中 PA 与脂联素的正相关减弱。